13-Aryl-substituted derivatives of the germacranolide argolide were synthesized by a Heck reaction with arylhalides. The structure of (E)-13-(4-methoxyphenyl)-3-oxogermacra-1(10),11(13)-dien-6α,12-olide was proved by an x-ray crystal structure analysis. Analgesic activity was found in the acetic-acid writhing test for the 13-arylgermacranolides.
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The work was supported financially by the Partnership Program for Basic Research, SB RAS and CIS countries, Project No. 108.
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Translated from Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2013, pp. 752–757.
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Esenbaeva, A.E., Shul’ts, E.E., Gatilov, Y.V. et al. Synthesis of 13-Aryl Derivatives of the Sesquiterpene Lactone Argolide and their Analgesic Activity. Chem Nat Compd 49, 875–881 (2013). https://doi.org/10.1007/s10600-013-0768-9
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DOI: https://doi.org/10.1007/s10600-013-0768-9