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The Association Between the Survivin C-31G Polymorphism and Gastric Cancer Risk in a Chinese Population

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Abstract

Introduction The C-31G polymorphism in the survivin promoter could de-represse the cell-cycle-dependent transcription of the human survivin gene, resulting in overexpression of survivin. This survivin mutation has only been studied on cervical carcinoma. However, no study has ever been conducted to evaluate the effect of the polymorphism on other cancers, including gastric cancer. Methods In this hospital-based, case–control study, we investigated the association between the survivin C-31G polymorphism and risk of gastric cancer in a Chinese population using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) protocols. Results No statistically significant association was observed between gastric cancer risk and the variant genotype (GG + GC). However, the variant genotype (GG + GC) was either associated with risk of distal gastric cancer (odds ratios = 0.50, 95% confidence interval = 0.30–0.83) or with risk of well-differentiated tumor (odds ratios = 0.46, 95% confidence interval = 0.22–0.97). Conclusion Our results demonstrate that the survivin C-31G polymorphism may be involved in distal gastric carcinogenesis and tumor differentiation in a Chinese population.

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Abbreviations

CI:

Confidence interval

OR:

Odds ratio

PCR:

Polymerase chain reaction

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Acknowledgments

This project was supported by grants from the National Natural Science Foundation of China (No. 30672486), and the Natural Science Foundation of Jiangsu Province (No. BK2006525), “333 Project”, “Qinglan Project,” and “Six RenCai Gaofeng (No. 07C008)” Funding for the Young Academic Leader of Jiangsu Province to Dr. Bin Wang.

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Authors and Affiliations

  1. Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, China

    Li Yang, Hanzhang Dong & Guoyu Chen

  2. Department of Pharmacy, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China

    Huaijun Zhu

  3. Department of Pharmacology, Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu Province, 210029, China

    Bo Zhou, Haijuan Gu, Naping Tang, Qingmin Sun, Rihong Cong & Bin Wang

  4. Dongzhi Health Inspection Bureau, Dongzhi, Anhui Province, 247200, China

    Hongli Yan

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  1. Li Yang
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  11. Bin Wang
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Correspondence to Bin Wang.

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Drs. L. Yang, H. Zhu, B. Zhou, and H. Gu contributed equally to this work.

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Yang, L., Zhu, H., Zhou, B. et al. The Association Between the Survivin C-31G Polymorphism and Gastric Cancer Risk in a Chinese Population. Dig Dis Sci 54, 1021–1028 (2009). https://doi.org/10.1007/s10620-008-0441-5

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  • DOI: https://doi.org/10.1007/s10620-008-0441-5

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