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Hyperoside Inhibits High-Glucose-Induced Vascular Inflammation In Vitro and In Vivo

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Abstract

Hyperoside, an active compound from the genera of Hypericum and Crataegus, was reported to have antioxidant, antihyperglycemic, anticancer, anti-inflammatory, and anticoagulant activities. Vascular inflammatory process has been suggested to play a key role in initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, in this study, we attempted to determine whether hyperoside can suppress vascular inflammatory processes induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. Data showed that HG induced markedly increased vascular permeability, monocyte adhesion, expressions of cell adhesion molecules (CAMs), formation of reactive oxygen species (ROS), and activation of nuclear factor (NF)-κB. Remarkably, all of the above-mentioned vascular inflammatory effects of HG were attenuated by pretreatment with hyperoside. Vascular inflammatory responses induced by HG are critical events underlying development of various diabetic complications; therefore, our results suggest that hyperoside may have significant therapeutic benefits against diabetic complications and atherosclerosis.

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Acknowledgments

This study was supported by the National Research Foundation of Korea (NRF) funded by the Korean government [MSIP] (Grant No. 2013-067053).

Conflict of Interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, 712-715, Republic of Korea

    Sae-Kwang Ku

  2. College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu, 702-701, Republic of Korea

    Soyoung Kwak & Jong-Sup Bae

  3. Daegyeong Institute for Regional Program Evaluation, Gyeongsan, 712-210, Republic of Korea

    O-Jun Kwon

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  1. Sae-Kwang Ku
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Correspondence to Jong-Sup Bae.

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Ku, SK., Kwak, S., Kwon, OJ. et al. Hyperoside Inhibits High-Glucose-Induced Vascular Inflammation In Vitro and In Vivo . Inflammation 37, 1389–1400 (2014). https://doi.org/10.1007/s10753-014-9863-8

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