Skip to main content

Advertisement

SpringerLink
Log in

Clinical outcomes of trabeculectomy vs. Ahmed glaucoma valve implantation in patients with penetrating keratoplasty

(Trabeculectomy vs. Ahmed galucoma valve in patients with penetrating keratoplasty)

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

The aim of this study was to compare the visual outcomes, intraocular pressure (IOP), and endothelial cell loss caused by trabeculectomy (TRAB) and Ahmed glaucoma valve (AGV) implantation in patients who had previously undergone penetrating keratoplasty (PKP). The data from all patients who underwent surgical treatment of glaucoma after PKP were reviewed at the Cornea Department of Haydarpasa Numune Education and Research Hospital. Eighteen patients who had undergone surgical treatment of glaucoma after PKP were included in this retrospective study. Time between PKP and glaucoma surgeries, visual acuity results, IOP results, endothelial cell counts (ECC) before the surgery, at 1st, 6th, and 12th month of surgery were recorded. Differences between two groups were evaluated. Mean loss of ECC was 315 cells/mm2 in the AGV group and 197 cells/mm2 in TRAB group at 12th month of glaucoma surgery. The difference between endothelial cell loss at 12th month of surgery was statistically significant and higher in AGV group (p < 0.001). The decrease in IOP was 64.2 % in AGV group and 46.9 % in TRAB group at 12th month of surgery. Both differences were statistically significant between 2 groups (p = 0.001, 0.001). TRAB successfully decreased both the IOP and endothelial cell loss in patients with post-PKP glaucoma. Ahmed glaucoma valve had a significantly better IOP lowering but higher endothelial cell loss effect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Clinical approach to corneal transplantation. In AAO Basic and Clinical Science Course. Section 8; 2005–2006: 425-446

  2. Goldberg DB, Schanzlin DJ, Brown SI (1981) Incidence of increased intraocular pressure after keratoplasty. Am J Ophthalmol 92:372–377

    Article  CAS  PubMed  Google Scholar 

  3. Foulks GN (1987) Glaucoma associated with penetrating keratoplasty. Ophthalmology 94:871–874

    Article  CAS  PubMed  Google Scholar 

  4. Karesh JW, Nirankari VS (1983) Factors associated with glaucoma after penetrating keratoplasty. Am J Ophthalmol 96:160–164

    Article  CAS  PubMed  Google Scholar 

  5. Wilson SE, Kaufman HE (1990) Graft failure after penetrating keratoplasty. Surv Ophthalmol 34:325–356

    Article  CAS  PubMed  Google Scholar 

  6. Kirkness CM, Moshegov C (1988) Post-keratoplasty glaucoma. Eye 2:19–26

    Article  Google Scholar 

  7. Fiore PM, Richter CU, Arzeno G et al (1989) The effect of anterior chamber depth on endothelial cell count after filtration surgery. Arch Ophthalmol 107:1609–1611

    Article  CAS  PubMed  Google Scholar 

  8. Ishioka M, Shimazaki J, Yamagami J et al (2000) Trabeculectomy with mitomycin C for post-keratoplasty glaucoma. Br J Ophthalmol 84:714–717

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kornmann HL, Gedde SJ (2015) Glaucoma management after corneal transplantation surgeries. Curr Opin Ophthalmol. doi:10.1097/ICU.0000000000000237

    Google Scholar 

  10. Allingham RR, Damji K, Freedman S et al (2004) Shield’s textbook of glaucoma, 5th edn. Lippincott Williams & Wilkins, Philadelphia, p 618

    Google Scholar 

  11. Kim CS, Yim JH, Lee EK et al (2008) Changes in corneal endothelial cell density and morphology after Ahmed glaucoma valve implantation during the first year of follow up. Clin Exp Ophthalmol 36:142–147

    Article  Google Scholar 

  12. Panda A, Prakash VJ, Dada T et al (2011) Ahmed glaucoma valve in post-penetrating-keratoplasty glaucoma: a critically evaluated prospective clinical study. Indian J Ophthalmol 59(3):185–189

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ayyala RS, Pieroth L, Vinals AF et al (1998) Comparison of mitomycin C trabeculectomy, glaucoma drainage device implantation, and laser neodymium:YAG cyclophotocoagulation in the management of intractable glaucoma after penetrating keratoplasty. Ophthalmology 105(8):1550–1556

    Article  CAS  PubMed  Google Scholar 

  14. Hollander DA, Giaconi JA, Holland GN et al (2010) Graft failure after penetrating keratoplasty in eyes with Ahmed valves. Am J Ophthalmol 150(2):169–178

    Article  PubMed  Google Scholar 

  15. Seah SR, Prata JA Jr, Minckler DS et al (1993) Mitomycin-C concentration in human aqueous humour following trabeculectomy. Eye 7:652–655

    Article  PubMed  Google Scholar 

  16. Storr-Paulsen T, Norregaard JC, Ahmed S et al (2008) Corneal endothelial cell loss after mitomycin C-augmented trabeculectomy. J Glaucoma 17(8):654–657

    Article  PubMed  Google Scholar 

  17. Sihota R, Sharma T, Agarwal HC (1998) Intraoperative mitomycin c and the corneal endothelium. Acta Ophthalmol Scand 76:80–82

    Article  CAS  PubMed  Google Scholar 

  18. Mc Dermott ML, Wang J, Shin DH (1994) Mitomycin and the human corneal endothelium. Arch Ophthalmol 112:533–537

    Article  CAS  Google Scholar 

  19. Singh J, O’Brien C, Chawla HB (1995) Success rate and complications of intraoperative 0,2 20 mg/ml mitomycin c in trabeculectomy surgery. Eye 9:460–466

    Article  PubMed  Google Scholar 

  20. Bourne WM (2001) Cellular changes in transplanted human corneas. Cornea 20:560–569

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

None of the authors has a financial or proprietary interest in a product, method, or material. There was no public or private financial support used in the study.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey

    Mehmet Orcun Akdemir

  2. Haydarpasa Numune Research and Education Hospital, Istanbul, Turkey

    Banu Torun Acar & Suphi Acar

  3. Department of Biostatistics, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey

    Furuzan Kokturk

Authors
  1. Mehmet Orcun Akdemir
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Banu Torun Acar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Furuzan Kokturk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Suphi Acar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mehmet Orcun Akdemir.

Ethics declarations

Conflict of interest

Authors have no conflict of interest to report.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Akdemir, M.O., Acar, B.T., Kokturk, F. et al. Clinical outcomes of trabeculectomy vs. Ahmed glaucoma valve implantation in patients with penetrating keratoplasty. Int Ophthalmol 36, 541–546 (2016). https://doi.org/10.1007/s10792-015-0160-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-015-0160-9

Keywords

Search

Navigation