Abstract
Background
Predictors of atrial fibrillation (AF) recurrence after catheter ablation (CA) are not fully defined. We hypothesized that 2D left atrial (LA) regional strain maps would help identify abnormal atrial substrate that increases susceptibility to AF recurrence post-CA.
Methods and Results
Sixty-three patients (63 ± 10 years, 60% male) underwent CA for symptomatic paroxysmal (75%) or persistent (25%) AF. Baseline LA mechanical function determined using speckle tracking echocardiography was compared between those with AF recurrence (AFR) and no recurrence post-CA. Bi-dimensional global and regional maps of LA wall velocity, strain, and strain rate (SR) were obtained during end ejection and early diastole. After 18 ± 12 months of follow-up, 34 patients were free of AFR post-CA. There were no differences in clinical characteristics, LA and LV volumes, and Doppler estimates of LV diastolic function and filling pressures at baseline between patients with recurrent AF and those that maintained sinus rhythm. However, the LA emptying fraction (55 ± 17% vs. 64 ± 14%, p = 0.04), global and regional systolic and diastolic strains, SR, and velocities were reduced in patients with recurrent AF. There was marked attenuation of peak LA lateral wall longitudinal strain (LS; 11 ± 7% vs. 20 ± 14%, p = 0.007) and SR (0.9 ± 0.4 vs.1.3 ± 0.6 s−1, p = 0.01). Multivariate analysis revealed lateral wall LS (odds ratio = 1.15, 95% CI = 1.02–1.28, p = 0.01) as an independent predictor of AFR.
Conclusions
Regional LA lateral wall LS is a pre-procedural determinant of AFR in patients undergoing CA, independent of LA enlargement. Characterization of atrial myocardial tissue properties by speckle tracking echo may aid the appropriate selection of adjunctive strategies and prognostication of patients undergoing CA.
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Abbreviations
- AF:
-
Atrial fibrillation
- AFR:
-
Atrial fibrillation recurrence
- CA:
-
Catheter ablation
- NR:
-
No recurrence group
- SR:
-
Strain rate
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Acknowledgments
This study was supported in part by National Heart, Lung, and Blood Institute R01 HL101240-01 grant. Dr. Jahangir is also supported by R01 HL089542-03.
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Mahek Mirza and Giuseppe Caracciolo both contributed equally to the work.
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Mirza, M., Caracciolo, G., Khan, U. et al. Left atrial reservoir function predicts atrial fibrillation recurrence after catheter ablation: a two-dimensional speckle strain study. J Interv Card Electrophysiol 31, 197–206 (2011). https://doi.org/10.1007/s10840-011-9560-6
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DOI: https://doi.org/10.1007/s10840-011-9560-6