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Red blood cell distribution width predicts outcome of cryoballoon-based atrial fibrillation ablation

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Abstract

Purpose

Elevated red blood cell distribution width (RDW) has been associated with atrial fibrillation (AF) in cross-sectional and prospective studies. In this study, we aim to evaluate the relation of preablation RDW levels to late AF recurrence following cryoablation.

Methods

A total of 299 patients with symptomatic paroxysmal or persistent AF despite ≥1 antiarrhythmic drug(s) who were scheduled for cryoballoon-based AF ablation were enrolled in this prospective study.

Results

A total of 299 patients (55.40 ± 10.60years, 49.20 % male) were involved and followed up at a median time of 24 (6–44) months. Patients with late AF recurrence had higher RDW levels (14.30 ± 0.93 vs. 13.52 ± 0.93 %, p < 0.001). Multivariate Cox proportional hazard regression analysis showed that RDW level was an independent predictor for late AF recurrence (HR 1.88, 95 % CI 1.41–2.50, p < 0.001) along with left atrial (LA) diameter (HR 3.09, 95 % CI 1.81–5.27, p < 0.001), duration of AF (HR 1.04, 95 % CI 1.01–1.07, p = 0.02), and early AF recurrence (HR 6.39, 95 % CI 3.41–11.97, p < 0.001). A cut-off level of 13.75 % for RDW predicted late AF recurrence following cryoballoon-based pulmonary vein isolation (PVI) with a sensitivity and specificity of 78.00 and 70.00 %, respectively.

Conclusion

These findings suggest that elevated RDW may be a predictor of late recurrence following cryoballoon-based AF ablation. Further studies are needed to establish its exact pathophysiologic and prognostic roles.

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Conflict of interest

The authors report no relationships that could be construed as a conflict of interest.

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Authors and Affiliations

  1. Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Kadri Murat Gurses, Muhammed Ulvi Yalcin, Duygu Kocyigit, Banu Evranos, Hikmet Yorgun, Mehmet Levent Sahiner, Ergun Baris Kaya, Necla Ozer, Mehmet Ali Oto & Kudret Aytemir

  2. Department of Cardiology, Samsun Training and Research Hospital, Samsun, Turkey

    Ahmet Hakan Ates

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  1. Kadri Murat Gurses
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  2. Muhammed Ulvi Yalcin
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  3. Duygu Kocyigit
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Correspondence to Duygu Kocyigit.

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Gurses, K.M., Yalcin, M.U., Kocyigit, D. et al. Red blood cell distribution width predicts outcome of cryoballoon-based atrial fibrillation ablation. J Interv Card Electrophysiol 42, 51–58 (2015). https://doi.org/10.1007/s10840-014-9959-y

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  • DOI: https://doi.org/10.1007/s10840-014-9959-y

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