Abstract
A unique method, based on the measurement of phosphorescence lifetimes, is reported for use in analytically detecting the widely used anti-inflammatory drug naproxen. The reciprocal phosphorescence lifetime of a ternary complex containing α-cyclodextrin and 2-bromo-6-methoxynaphthalene increases linearly with naproxen concentration and has a quenching constant of 2.1 ± 0.05 × 106 M−1 s−1. Similar behavior is observed for quenching by the sodium salt of naproxen that has a quenching constant of 1.8 × 106 ± 0.05 M−1 s−1. The experimental sensitivity is sufficient to permit measurements of naproxen concentrations differing by 11 μg/ml. Phosphorescence lifetime measurements reveal that the quenching mechanism does not involve displacement of the unrelaxed triplet-state guest molecule by naproxen from the complex and may occur by energy transfer or electron transfer.
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This research was supported by the National Science Foundation under grant number 0240213 for which the authors express their gratitude.
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Bussey, R.O., Schuh, M.D. Quantitation of naproxen by quenching of phosphorescence from a ternary complex of 2-bromo-6-methoxynaphthalene and α-cyclodextrin. J Incl Phenom Macrocycl Chem 57, 163–167 (2007). https://doi.org/10.1007/s10847-006-9202-2
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DOI: https://doi.org/10.1007/s10847-006-9202-2