Skip to main content
SpringerLink
Log in

Sodium silicate bonded borate glass scaffolds for tissue engineering

  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

Borate and silicate glass particles and microspheres with size distributions in the range of approximately 100–400 micron were loosely compacted and bonded by sodium silicate solution to prepare resorbable, porous glass constructs with porosity 30–50%. Conversion of the binding borate glass to hydroxyapatite was investigated by measuring the weight loss of the constructs in a solution of 0.25 M K2HPO4 with a pH value of 9.0 at 37 °C, as a function of time. Almost full conversion of the borate glass to hydroxyapatite was achieved in less than 6 days. X-ray diffraction revealed an initially amorphous product that subsequently crystallized to hydroxyapatite.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Li W-J, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, Tuan RS (2005) Biomaterials 26:599

    Article  CAS  Google Scholar 

  2. Vacanti JP, Langer R (1999) The Lancet 354(Suppl. 1):32

    Article  Google Scholar 

  3. Stock UA, Vacanti JP (2001) Annu Rev Med 52:443

    Article  CAS  Google Scholar 

  4. Kneser U, Schaefer DJ, Munder B, Klemt C, Andree C, Stark GB (2002) Min Invas Ther Alllied Technol 11:107

    Article  Google Scholar 

  5. Vats A, Tolley NS, Polak JM, Gough JE (2003) Clin Otolaryngol 28:165

    Article  CAS  Google Scholar 

  6. Lichtenberg A, Dumlu G, Walles T, Maringka M, Ringes-Lichtenberg S, Ruhparwar A, Mertsching H, Haverich A (2005) Biomaterials 26:555

    Article  CAS  Google Scholar 

  7. Goldstein SA, Patil PV, Moalli MR (1999) Clin Orthop 357S:S419

    Article  Google Scholar 

  8. Yoon JJ, Park TG (2001) J Biomed Mater Res 55:401

    Article  CAS  Google Scholar 

  9. Silver IA, Deas J, Erecińska M (2001) Biomaterials 22:175

    Article  CAS  Google Scholar 

  10. Siebers MC, ter Brugge PJ, Walboomers XF, Jansen JA (2005) Biomaterials 26:137

    Article  CAS  Google Scholar 

  11. Hench LL (1991) J Am Ceram Soc 74:1487

    Article  CAS  Google Scholar 

  12. Hench LL, Splinter RJ, Allen WC, Greenlee TJ Jr (1971) J Biomed Mater Res 2:117

    Article  Google Scholar 

  13. Bosetti M, Zanardi L, Hench LL, Cannas M (2003) J Biomed Mater Res 64A:189

    Article  CAS  Google Scholar 

  14. Ramay HR, Zhang M (2003) Biomaterials 24:3293

    Article  CAS  Google Scholar 

  15. Boyan BD, Niederauer G, Kieswetter K, Leatherbury NC, Greenspan DC (1999) US Patent No. 5977204

  16. Conzone SD, Brown RF, Day DE, Ehrhardt GJ (2002) J Biomed Mater Res 60:260

    Article  CAS  Google Scholar 

  17. Day DE, White JE, Brown RF, McMenamin KD (2003) Glass Technol 44:75

    CAS  Google Scholar 

  18. Marion NW, Liang W, Reilly G, Day DE, Rahaman MN, Mao JJ (2005) Mech Adv Mater Struct (MAMS) 12(3):239

    Article  CAS  Google Scholar 

  19. Rahaman MN, Liang W, Day DE, Marion NW, Reilly G, Mao JJ (2005) Adv Bioceram Biocomposites 26(6). A Collection of Papers Presented at the 29th International Conference on Advanced Ceramics and Composites 2005, pp 3–10

  20. Liang W, Rűssel C, Day DE (2006) J Mater Res 21(1):125

    Article  CAS  Google Scholar 

  21. Liang W, Rűssel C (2006) J Mater Sci 41:3787

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This project is financially sponsored by Shanghai Pujiang Programme. The authors wish to acknowledge the valuable discussion with Prof. D E Day in the Materials Research Center, University of Missouri-Rolla.

Author information

Authors and Affiliations

  1. Research Institute of Biomaterials, East China University of Science and Technology, Shanghai, China

    Wen Liang & Meng Wang

  2. Materials Research Center, University of Missouri-Rolla, Rolla, MO, USA

    Delbert E. Day

  3. Otto-Schott-Institut, Universität Jena, Jena, Germany

    Christian Rüssel

Authors
  1. Wen Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Meng Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Delbert E. Day
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Christian Rüssel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wen Liang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liang, W., Wang, M., Day, D.E. et al. Sodium silicate bonded borate glass scaffolds for tissue engineering. J Mater Sci 42, 10138–10142 (2007). https://doi.org/10.1007/s10853-007-2101-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-007-2101-0

Keywords

Search

Navigation