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Novel chelate-setting calcium-phosphate cements fabricated with wet-synthesized hydroxyapatite powder

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Abstract

The hydroxyapatite (HAp) powder preparation process was optimized to fabricate inositol phosphate-HAp (IP6-HAp) cement with enhanced mechanical properties. Starting HAp powders were synthesized via a wet chemical process. The effect of the powder preparation process on the morphology, crystallinity, median particle size, and specific surface area (SSA) of the cement powders was examined, together with the mechanical properties of the resulting cement specimens. The smallest crystallite and median particle sizes, and the highest SSA were obtained from ball-milling of as-synthesized HAp powder under wet conditions and then freeze-drying. IP6-HAp cement fabricated with this powder had a maximum compressive strength of 23.1 ± 2.1 MPa. In vivo histological studies using rabbit models revealed that the IP6-HAp cements were directly in contact with newly formed and host bones. Thus, the present chelate-setting HAp cement is promising for application as a novel paste-like artificial bone.

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Acknowledgments

The present study was supported in part by a Grant for Practical Application of University R&D Results under the Matching Fund Method from the New Energy and Industrial Technology Development Organization (NEDO), Japan.

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Authors and Affiliations

  1. Kanagawa Academy of Science and Technology (KAST), KSP East 404, 3-2-1 Sakado, Takatsu-ku, Kawasaki, 213-0012, Japan

    Toshiisa Konishi, Minori Mizumoto, Michiyo Honda, Ken Ishii, Morio Matsumoto & Mamoru Aizawa

  2. Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, 214-8571, Japan

    Toshiisa Konishi & Mamoru Aizawa

  3. Showa Ika Kohgyo Co., Ltd., 8-7, Haneinishimachi, Toyohashi, 441-8571, Japan

    Yukiko Horiguchi & Kazuya Oribe

  4. Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Hikaru Morisue, Ken Ishii, Yoshiaki Toyama & Morio Matsumoto

Authors
  1. Toshiisa Konishi
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  2. Yukiko Horiguchi
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  3. Minori Mizumoto
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  4. Michiyo Honda
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  5. Kazuya Oribe
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  6. Hikaru Morisue
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  7. Ken Ishii
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  8. Yoshiaki Toyama
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  9. Morio Matsumoto
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  10. Mamoru Aizawa
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Correspondence to Toshiisa Konishi.

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Konishi, T., Horiguchi, Y., Mizumoto, M. et al. Novel chelate-setting calcium-phosphate cements fabricated with wet-synthesized hydroxyapatite powder. J Mater Sci: Mater Med 24, 611–621 (2013). https://doi.org/10.1007/s10856-012-4834-9

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  • DOI: https://doi.org/10.1007/s10856-012-4834-9

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