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Biocompatible bacterial cellulose membrane in dural defect repair of rat

  • Biocompatibility Studies
  • Original Research
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Abstract

Duraplasty is necessary in nearly 30% of all neurological surgeries. Different tissues and materials have been evaluated in dura mater repair or as dural substitutes in neurosurgery. The aim was to evaluate the biocompatibility of the bacterial cellulose (BC) membranes, produced from sugarcane molasses, for dural defect repair in rats. Forty adults males Wistar rats divided into two groups: a control (ePTFE) and an experimental (BC). Bilateral frontoparietal craniectomy was performed, and a dural defect was created. The arachnoid underlying defect was disrupted with a narrow hook. The animals were observed for 120 days. There were no cases of infection, cerebrospinal fluid fistulae, delayed hemorrhages, behavior disturbances, seizures and palsies. The BC membrane showed to have suitable biocompatibility properties, was not induced immune reaction, nor chronic inflammatory response and absence of neurotoxicity signals.

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Acknowledgements

Research Performed at Center for Experimental Surgery of the Federal University of Pernambuco UFPE, Recife-PE, Brazil. Research Performed at collaboration with the Laboratory of Human Reproduction of the University of São Paulo (UNIFESP), Laboratory of Immunopathology Keizo Asami (LIKA), and the Department of Nuclear Energy (DEN) of the Federal University of Pernambuco, Recife/PE, Brazil. The English version of this text has been revised by a native speaker, Sidney Pratt, Canadian, BA, MAT (The Johns Hopkins University), RSA diploma (TEFL) University of Cambridge.

Funding

National Council for Scientific and Technological Development (CNPq).

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Authors and Affiliations

  1. Center for Experimental Surgery, Department of Surgery, Center for Health Sciences, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil

    Frederico de Melo Tavares de Lima, Flávia Cristina Morone Pinto & José Lamartine de Andrade Aguiar

  2. Department of Physiology and Pharmacology, Center for Health Sciences, Federal University of Pernambuco, Recife, Pernambuco, Brazil

    Belmira Lara da Silveira Andrade-da-Costa

  3. Immunopathology Laboratory Keizo Asami, LIKA, Federal University of Pernambuco, UFPE, Recife, Pernambuco, Brazil

    Jaiurte Gomes Martins da Silva & Olávio Campos Júnior

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  1. Frederico de Melo Tavares de Lima
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  2. Flávia Cristina Morone Pinto
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Correspondence to Flávia Cristina Morone Pinto.

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Lima, F.d.M.T., Pinto, F.C.M., Andrade-da-Costa, B.L.d.S. et al. Biocompatible bacterial cellulose membrane in dural defect repair of rat. J Mater Sci: Mater Med 28, 37 (2017). https://doi.org/10.1007/s10856-016-5828-9

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  • DOI: https://doi.org/10.1007/s10856-016-5828-9

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