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Electrospun gelatin–polyethylenimine blend nanofibrous scaffold for biomedical applications

  • Tissue Engineering Constructs and Cell Substrates
  • Original Research
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Abstract

In this study, gelatin–polyethylenimine blend nanofibers (GEL/PEI) were fabricated via electrospinning with different ratios (9:1, 6:1, 3:1) to integrate the properties of both the polymers for evaluating its biomedical application. From scanning electron microscopy, the average diameter of blend nanofibers (265 ± 0.074 nm to 340 ± 0.088 nm) was observed to be less than GEL nanofibers (403 ± 0.08 nm). The incorporation of PEI with gelatin resulted in improved thermal stability of nanofibers whereas the Young’s modulus was observed to be higher at 9:1 ratio when compared with other ratios. The in vitro studies showed that the GEL/PEI nanofibers with 9:1 ratio promoted better cell adhesion and viability. GEL/PEI nanofibers with 9:1 and 6:1 showed hemolysis within the permissible limits. From the results, it could be interpreted that GEL/PEI nanofibers with 9:1 ratio proved to be a better scaffold thereby making them a potential candidate for tissue engineering applications.

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Acknowledgements

Authors would like to thank The Director, CSIR-CLRI for providing the necessary infrastructure and resources to carry out the research work.

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Authors and Affiliations

  1. Biological Materials Laboratory, Council of Scientific and Industrial Research, Central Leather Research Institute, Adyar, Chennai, 600020, India

    Rachita Lakra, Manikantan Syamala Kiran & Purna Sai Korrapati

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  1. Rachita Lakra
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  2. Manikantan Syamala Kiran
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  3. Purna Sai Korrapati
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Correspondence to Purna Sai Korrapati.

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Lakra, R., Kiran, M.S. & Korrapati, P.S. Electrospun gelatin–polyethylenimine blend nanofibrous scaffold for biomedical applications. J Mater Sci: Mater Med 30, 129 (2019). https://doi.org/10.1007/s10856-019-6336-5

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  • DOI: https://doi.org/10.1007/s10856-019-6336-5

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