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A Highly Selective and Sensitive Probe for Cu2+ Based on Rhodamine-Pyridazine Conjugate and its Application

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Abstract

A naked-eye fluorescent chemodosimeter based on rhodamine-pyridazine conjugate L was synthesized and characterized. L exhibited high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Cu2+ in aqueous solution with a broad pH span (1–10). The detection limit of the probe was shown to be up to 0.336 ppm. A simple paper test-strip system for the rapid monitoring of Cu2+ was developed, indicating its convenient use in environmental samples. Furthermore, fluorescence imaging experiments of Cu2+ in living MGC803 cells demonstrated its value of practical applications in biological systems.

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Acknowledgments

This work was supported by the National Science Foundation of China (Nos. 20972143, 20972130) and Program for New Century Excellent Talents in University (NCET-11- 0950).

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Authors and Affiliations

  1. Phosphorus Chemical Engineering Research Center of Henan Province, The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China

    Peigang Ding, Shao Li, Junye Cheng, Yufen Zhao & Yong Ye

  2. School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, China

    Linchao Yang & Zhenji Wang

  3. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China

    Yufen Zhao & Yong Ye

Authors
  1. Peigang Ding
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  2. Shao Li
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  3. Linchao Yang
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  4. Junye Cheng
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  5. Zhenji Wang
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  6. Yufen Zhao
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  7. Yong Ye
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Corresponding author

Correspondence to Yong Ye.

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Ding, P., Li, S., Yang, L. et al. A Highly Selective and Sensitive Probe for Cu2+ Based on Rhodamine-Pyridazine Conjugate and its Application. J Fluoresc 25, 15–24 (2015). https://doi.org/10.1007/s10895-014-1480-2

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  • DOI: https://doi.org/10.1007/s10895-014-1480-2

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