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Comparative instrumental investigations of some bile acids

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Abstract

In this paper, we present the spectroscopic description (by the means of UATR-FTIR spectroscopy) for four naturally occurring bile acids, namely lithocholic acid (LC), taurocholic acid sodium salt hydrate (TC), taurodeoxycholic acid sodium salt hydrate (TDC) and chenodeoxycholic acid (CDC), as well as their thermal behaviour in dynamic oxidative atmosphere, by TG/DTG/HF means. It was shown that all samples have a good thermal stability, favourized by the presence of cholan-24-oic structural moiety in all samples, as well as the solid-state structure (intermolecular H-bondings for the carboxylic acids CDC and LC and saline structures for TDC and TC, respectively). These data are simple, but of great interest in identifying the presence of these compounds by fast, reproducible and precise instrumental techniques in complex mixtures, such as biliary stones.

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Acknowledgements

This work was supported by a grant financed by the University of Medicine and Pharmacy “Victor Babes” Timisoara (Grant PIII-C3-PCFI-2016/2017, acronym STONES).

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Author notes

  1. Ionut Ledeti, Agneta Maria Pusztai and Marius Murariu have contributed equally to this work.

Authors and Affiliations

  1. Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timişoara, Romania

    Ionut Ledeti, Denisa Circioban & Adriana Ledeti

  2. Faculty of Medicine, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timişoara, Romania

    Agneta Maria Pusztai, Marius Murariu, Sorin Olariu, Codrut Ivan & Petru Matusz

  3. Research Centre for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115, Timişoara, Romania

    Gabriela Vlase & Titus Vlase

Authors
  1. Ionut Ledeti
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  2. Agneta Maria Pusztai
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  3. Marius Murariu
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  4. Sorin Olariu
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  5. Codrut Ivan
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  6. Denisa Circioban
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  7. Gabriela Vlase
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  8. Adriana Ledeti
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  9. Titus Vlase
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  10. Petru Matusz
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Corresponding author

Correspondence to Adriana Ledeti.

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Ledeti, I., Pusztai, A.M., Murariu, M. et al. Comparative instrumental investigations of some bile acids. J Therm Anal Calorim 134, 1345–1350 (2018). https://doi.org/10.1007/s10973-018-7163-5

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  • DOI: https://doi.org/10.1007/s10973-018-7163-5

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