Abstract
Several mechanisms both inside and outside the central nervous system (CNS) collaborate to control feeding. The hypothalamus received food-related messages from different regions of the brain, and exports appropriate output through specific hypothalamic nuclei. One of the most important of these hypothalamic nuclei is the lateral hypothalamus area (LHA). In this review, multiple valid papers from electronic sources (including Web of Science, Scopus, PubMed, SID, Google Scholar, and ISI databases) were used; which in them the role of LHA in the central regulation of feeding investigated. The hypothalamus is responsible for the central control of food intake in the CNS. The arcuate nucleus, paraventricular nucleus, and LHA are specific regions in the hypothalamus that regulate food intake. The LHA is considered to be the center of hunger or feeding among these nuclei. With the interaction of orexigenic and anorexigenic neurons, as well as various neurotransmitters in several neuronal pathways, this nucleus produces increased food intake. The LHA eventually improved food intake via extensive brain connections. The LHA via various neurons and synaptic connections with other special hypothalamic nuclei involved in the control of nutritional behavior (graphical abstract) stimulated food intake.
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Abbreviations
- LHA:
-
Lateral hypothalamus area
- PNS:
-
Peripheral nervous system
- ARC:
-
Arcuate nucleus
- PVN:
-
Paraventricular nucleus
- AgRP:
-
Agouti-related protein
- POMC:
-
Pro-opiomelanocortin
- BNTS:
-
Bed nucleus of the stria terminalis
- GABA:
-
Gamma-aminobutyric acid
- GI:
-
Glucose-inhibition
- GE:
-
Glucose-excited
- CART:
-
Cocaine-amphetamine regulated transcript
- BBB:
-
Blood–brain barrier
- GLUTs:
-
Glucose transporters
- SGLTs:
-
Sodium–glucose co-transporters
- NPYR:
-
Neuropeptide Y receptor
- α-MSH:
-
α-Melanocortin stimulating hormone
- MC4R:
-
Melanocortin stimulating 4 receptor
- ICV:
-
Intracerebroventricular injection
- CRH:
-
Corticotropin-releasing hormone
- Lp-R:
-
Leptin receptor
- CNS:
-
Central nervous system
- GPCR:
-
G protein-coupled receptor
- OXR:
-
Orexin receptors
- IR:
-
Insulin receptors
- CAMP:
-
Cyclic adenosine monophosphate
- GHSR1a:
-
Growth hormone secretagogue receptor 1a
- NTs-R:
-
Neurotensin receptor
- GalR1:
-
Galanin-receptor1
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The authors thank the Ferdowsi University of Mashhad for their cooperation and support of this article.
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Yousefvand, S., Hamidi, F. Role of Lateral Hypothalamus Area in the Central Regulation of Feeding. Int J Pept Res Ther 28, 83 (2022). https://doi.org/10.1007/s10989-022-10391-4
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DOI: https://doi.org/10.1007/s10989-022-10391-4