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Current state of knowledge of hepatic encephalopathy (Part V): clinical efficacy of L-ornithine-L-aspartate in the management of HE

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Abstract

In cirrhotic patients with portosystemic encephalopathy, OA has confirmed its efficacy both in uncontrolled clinical trials and more recently in placebo-controlled double-blind studies in patients with manifest hepatic encephalopathy and hyperammonemia. OA improved performance in Psyhometric Tests as well as mental state gradation. The therapy had little side effects, increasing with higher intravenously administered dosages, and was well tolerated after oral and parenteral administration.

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Acknowledgment

The authors would like to express thanks to Prof. Kevin Mullen help and advice in the production of this manuscript.

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  1. Düsseldorf, Germany

    Gerald Kircheis

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  1. Gerald Kircheis
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Correspondence to Gerald Kircheis.

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Kircheis, G. Current state of knowledge of hepatic encephalopathy (Part V): clinical efficacy of L-ornithine-L-aspartate in the management of HE. Metab Brain Dis 31, 1365–1367 (2016). https://doi.org/10.1007/s11011-016-9912-0

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  • DOI: https://doi.org/10.1007/s11011-016-9912-0

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