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[TBP]2SO4 ionic liquid catalyst for 4MCR of pyridazinoindazole, indazolophthalazine and pyrazolophthalazine derivatives

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Abstract

Tetrabutyl phosphonium sulfate ([TBP]2SO4), as novel room-temperature ionic liquid (RTIL), was synthesized by a simple cost-effective method, characterized by 1H, 13C, 31P NMR and FT-IR spectrophotometry. The newly prepared catalyst was used as an efficient catalyst in some four multicomponent reactions (4MCRs) e. g., to synthesis pyridazino[1,2-a]indazole, indazolo[2,1-b]phthalazine and pyrazolo[1,2-b]phthalazine. This green method has several advantages such as short reaction time, using simple methods to prepare catalysts and products, easy operation and high efficiency of products. In addition, the catalyst can be easily recovered and reused several times with reduced average activity.

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Acknowledgements

The authors express appreciation to University of Guilan, Faculty Research Committee for its support of this investigation.

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Authors and Affiliations

  1. Department of Chemistry, University of Guilan, University Campus 2, Rasht, Iran

    Najmeh Amirmahani

  2. Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

    Najmeh Amirmahani & Mohammad Malakootian

  3. Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran

    Nosrat O. Mahmoodi

  4. Pharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran

    Abbas Pardakhty

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  1. Najmeh Amirmahani
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  2. Nosrat O. Mahmoodi
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  3. Mohammad Malakootian
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  4. Abbas Pardakhty
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Correspondence to Nosrat O. Mahmoodi.

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Amirmahani, N., Mahmoodi, N.O., Malakootian, M. et al. [TBP]2SO4 ionic liquid catalyst for 4MCR of pyridazinoindazole, indazolophthalazine and pyrazolophthalazine derivatives. Mol Divers 26, 15–25 (2022). https://doi.org/10.1007/s11030-020-10153-8

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  • DOI: https://doi.org/10.1007/s11030-020-10153-8

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