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A molecular genome scan to identify DNA segments associated with live weight in Japanese quail

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Abstract

Japanese quail is an animal model in biological studies and also a commercial bird for eggs and meat production. This study was conducted to map quantitative trait loci (QTL) affecting live weight in Japanese quail. An F2 mapping population was developed by crossing two diverse lines (meat type and egg layer) of Japanese quail. A total number of 34 F1 and 422 F2 progeny were produced by reciprocal crossing of eight pairs of parental birds. All the birds from three generations were genotyped for SSR markers that were spread across all the autosomal linkage groups. The studied traits were hatching weight and live weights at 1–5 weeks of age. QTL analysis was conducted by the regression interval mapping. Significant QTL were detected on chromosomes 1, 2, 3 (chromosome-wide significant) and 5 (genome-wide significant, P < 0.05) for body weight. Although the additive effect of the detected QTL on chromosome 5 was significant, the dominance and imprinting effects were not significant. This finding is the first report of a genome-wide significant QTL associated with live weight in Japanese quail. Our results point out to candidate DNA regions affecting live weight, a trait of great economic relevance to the Japanese quail breeding. Although these results enhance our current knowledge about the genetic control of live weight in the Japanese quail, it should be noted that the initial QTL results from the experimental designs such as backcross or F2 cannot be applied directly to the breeding programs and require further validation within the commercial lines.

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Authors and Affiliations

  1. State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China

    A. Esmailizadeh & Dong-Dong Wu

  2. Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, PO Box 76169-133, Kerman, Iran

    M. Iranmanesh, A. Esmailizadeh, M. R. Mohammad Abadi & Elmira Zand

  3. Kunming College of Life Science, University of Chinese Academy of Sciences, 650204, Kunming, China

    Dong-Dong Wu

  4. Department of Animal Science, Faculty of Agriculture, University of Jiroft, PO Box 364, Jiroft, Kerman, Iran

    M. S. Mokhtari

Authors
  1. M. Iranmanesh
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  2. A. Esmailizadeh
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  3. M. R. Mohammad Abadi
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  4. Elmira Zand
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  5. M. S. Mokhtari
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  6. Dong-Dong Wu
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Corresponding authors

Correspondence to A. Esmailizadeh or Dong-Dong Wu.

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Iranmanesh, M., Esmailizadeh, A., Mohammad Abadi, M.R. et al. A molecular genome scan to identify DNA segments associated with live weight in Japanese quail. Mol Biol Rep 43, 1267–1272 (2016). https://doi.org/10.1007/s11033-016-4059-y

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  • DOI: https://doi.org/10.1007/s11033-016-4059-y

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