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Relationship Between Susceptibility of Candida spp. Isolates to Amphotericin B and Death or Survival of Patients with Candidemia Episodes

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Abstract

In this study, the susceptibility to amphotericin B of Candida spp. isolates obtained from patients with candidemia was related to their respective clinical outcomes. The susceptibility tests were carried out in three culture media: RPMI 1640, Antibiotic medium 3 and Yeast Nitrogen Base dextrose. We have found that minimal inhibitory concentrations and minimal fungicidal concentrations obtained using AM3 and YNBd media were significantly higher for Candida spp. from patients who died than for those from patients who survived the candidemia (P < 0.05). The assays with RPMI 1640 medium did not show these differences.

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Authors and Affiliations

  1. Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Rua dos Andradas 1985/201, Santa Maria, RS, Brazil

    Sydney Hartz Alves, Everton Boff, Patricia Pozzatti, Liliane A. Scheid, Érico de Loreto & Janio Morais Santurio

  2. Hospital Universitário de Santa Maria, Santa Maria, RS, Brazil

    Loiva T. Ottoneli Oliveira

  3. Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil

    Valério Aquino

  4. Complexo Hospitalar Santa Casa, Porto Alegre, RS, Brazil

    Luiz Carlos Severo

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  1. Sydney Hartz Alves
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Correspondence to Sydney Hartz Alves.

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Alves, S.H., Boff, E., Pozzatti, P. et al. Relationship Between Susceptibility of Candida spp. Isolates to Amphotericin B and Death or Survival of Patients with Candidemia Episodes. Mycopathologia 167, 65–71 (2009). https://doi.org/10.1007/s11046-008-9159-3

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  • DOI: https://doi.org/10.1007/s11046-008-9159-3

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