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Correlation of MMP1 and TIMP1 expression with pituitary adenoma fibrosis

  • Laboratory Investigation - human/animal tissue.
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Abstract

Objective To explore the correlation of matrix metalloproteinase-1 (MMP1) and tissue inhibitor of metalloproteinase-1 (TIMP1) with pituitary adenoma fibrosis. Methods Thirty-eight pituitary adenoma specimens were divided into fibrous group (6 patients) and non-fibrous group (32 patients). MMP1 and TIMP1 expression was detected by RT-PCR and immunohistochemistry. The collagen content was determined by Sirius scarlet staining. Results In fibrous and non-fibrous group: (1) the collagen content was 20.95 ± 8.42% and 7.98 ± 5.18% respectively, and there was a statistical significance (P < 0.01). (2) The expression of MMP1mRNA was 0.47 ± 0.40 and 0.59 ± 0.54 respectively and its protein expression was 0.12 ± 0.09 and 0.13 ± 0.09 respectively, and there was no statistical significance (P > 0.05). Their expression was not related to collagen content (P > 0.05). (3) The expression of TIMP1mRNA was 1.61 ± 1.09 and 0.79 ± 0.59 respectively and its protein expression was 0.58 ± 0.11 and 0.32 ± 0.18 respectively, and there was a statistical significance (P < 0.01). Their expression was related to collagen content (P < 0.01). Conclusion The pathological features of pituitary adenoma fibrosis are excessive collagen deposition. High expression of TIMP1 may be an important cause.

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Authors and Affiliations

  1. Department of Neurosurgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China

    Hui Wang, Wen-Sheng Li, De-Jin Shi, Zhuo-Peng Ye, Feng Tai, Hai-Yong He, Chao-Feng Liang, Jin Gong & Ying Guo

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  1. Hui Wang
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  2. Wen-Sheng Li
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Correspondence to Ying Guo.

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Wang, H., Li, WS., Shi, DJ. et al. Correlation of MMP1 and TIMP1 expression with pituitary adenoma fibrosis. J Neurooncol 90, 151–156 (2008). https://doi.org/10.1007/s11060-008-9647-9

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