Abstract
Active immunization against cholecystokinin fragments 31–33 (CCK-3) and 30–33 (CCK-4) results in long-lasting changes of albino rats’ behavior. CCK-3 and CCK-4 covalently linked to antigen-carrier evokes the suppression of the anxiety, decreases some signs of depression-like behavior and changes the level of bioamines and their catabolites in striatum at least for two months after immunization. These data can provide a perspective approach to the problem of long term correction of behavior.
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This work was supported by the Russian Fund of Fundamental Investigations, Grant No. 02–04–4(8083)
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Ashmarin, I.P., Danilova, R.A., Obukhova, M.F. et al. Long-lasting Changes of Albino Rats Behavior and Brain Bioamines Content After Immunization Against Cholecystokinin-3 and -4. Neurochem Res 32, 395–399 (2007). https://doi.org/10.1007/s11064-006-9223-7
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DOI: https://doi.org/10.1007/s11064-006-9223-7