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MicroRNA-21 in the Pathogenesis of Traumatic Brain Injury

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Abstract

MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is involved in the signaling pathways of inflammation, neuronal apoptosis, reactive gliosis, disruption of blood brain barrier, angiogenesis and recovery process induced by physical exercises in TBI. Hence, miR-21 is now considered as a potential therapeutic target of TBI. We review the correlative literature and research progress regarding the roles of miR-21 in TBI in this article.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81272791, 81502159), Jiangsu Young Medical Talents (QNRC2016190).

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  1. Department of Neurosurgery, Wuxi People’s Hospital of Nanjing Medical University, Wuxi, People’s Republic of China

    Wei Ji, Jiantong Jiao, Chao Cheng & Junfei Shao

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  1. Wei Ji
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Correspondence to Junfei Shao.

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Ji, W., Jiao, J., Cheng, C. et al. MicroRNA-21 in the Pathogenesis of Traumatic Brain Injury. Neurochem Res 43, 1863–1868 (2018). https://doi.org/10.1007/s11064-018-2602-z

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