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Integrative Multi-Omics Research in Cerebral Palsy: Current Progress and Future Prospects

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Abstract

Cerebral palsy (CP) describes a heterogeneous group of non-progressive neurodevelopmental disorders affecting movement and posture. The etiology and diagnostic biomarkers of CP are a hot topic in clinical research. Recent advances in omics techniques, including genomics, epigenomics, transcriptomics, metabolomics and proteomics, have offered new insights to further understand the pathophysiology of CP and have allowed for identification of diagnostic biomarkers of CP. In present study, we reviewed the latest multi-omics investigations of CP and provided an in-depth summary of current research progress in CP. This review will offer the basis and recommendations for future fundamental research on the pathogenesis of CP, identification of diagnostic biomarkers, and prevention strategies for CP.

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Funding

This work was supported by National stem cell clinical research registered project (CMR-20161129-1003) to JL.

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Authors and Affiliations

  1. Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, No. 193, Lianhe Road, Shahekou District, 116011, Dalian City, Liaoning Province, P.R. China

    Chengqi Xin, Xin Guan, Liang Wang & Jing Liu

  2. Dalian Innovation Institute of Stem Cell and Precision Medicine, No. 57, Xinda Street, Dalian High-Tech Park, 116023, Dalian City, Liaoning Province, P.R. China

    Chengqi Xin, Xin Guan, Liang Wang & Jing Liu

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  1. Chengqi Xin
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Contributions

CQX and JL conceived the manuscript, CQX wrote the manuscript, CQX and XG performed the literature search and data collection, CQX, LW and JL revised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Jing Liu.

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Xin, C., Guan, X., Wang, L. et al. Integrative Multi-Omics Research in Cerebral Palsy: Current Progress and Future Prospects. Neurochem Res 48, 1269–1279 (2023). https://doi.org/10.1007/s11064-022-03839-y

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