Skip to main content

Advertisement

SpringerLink
Log in

Studies of the effects of new progestins from the pentarane series on viability, epidermal growth factor receptor expression, and apoptosis of cultured HeLa and MCF-7 cells

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Abstract

The effects of six new steroids of the pregnane series, with substituents at the 16α, 17α, and-or 3 and 19 positions of the steroid skeleton, on the viability of cultured breast cancer MCF-7 and cervical cancer HeLa cells were studied. The results showed that 3-keto-4-dehydrosteroids with a 16α,17α-spiropentane substituent and 3-keto-4-dehydro-16α,17α-cyclohexanopregnanes with 3-or 19-oxyimino groups decreased the viability of both types of cell culture. These compounds had negative influences on the expression of the epidermal growth factor receptor (EGFR) and induced apoptosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. V. Kamernitskii and I. S. Levina, Bioorg. Khimiya, 31, No. 2, 115–129; No. 3, 199–209 (2005).

    CAS  Google Scholar 

  2. M. S. Contoneo, W. A. Fritz, and C. A. Lamartiniere, Food Chem. Toxicol., 43, No. 5, 637–645 (2005).

    Article  Google Scholar 

  3. N. Sunil, M. J. Bennett, and S. Z. Haslam, Endocrinology, 143, No. 8, 2953–2960 (2002).

    Article  PubMed  CAS  Google Scholar 

  4. B. Formby and T. S. Wiley, FASEB J., 13, No. 8, 793–803 (1999).

    Google Scholar 

  5. I. S. Levina, L. E. Kulikova, A. V. Kamernitskii, et al., Izv. Akad. Nauk. Ser. Khim., No. 11, 2579–2584 (2006).

  6. T. Mosmann, J. Immunol. Meth., 65, No. 1, 55–63 (1983).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

    I. S. Levina, L. E. Kulikova & A. V. Kamernitskii

  2. Russian State Medical University, Moscow, Russia

    A. V. Semeikin, V. B. Vetchinkina, K. A. Atroshkin, V. V. Banin & N. L. Shimanovskii

Authors
  1. A. V. Semeikin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. S. Levina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. E. Kulikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. V. Kamernitskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. B. Vetchinkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. A. Atroshkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. V. V. Banin
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. N. L. Shimanovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 5, pp. 27–29, May, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Semeikin, A.V., Levina, I.S., Kulikova, L.E. et al. Studies of the effects of new progestins from the pentarane series on viability, epidermal growth factor receptor expression, and apoptosis of cultured HeLa and MCF-7 cells. Pharm Chem J 42, 258–261 (2008). https://doi.org/10.1007/s11094-008-0102-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-008-0102-1

Keywords

Search

Navigation