Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage.
Similar content being viewed by others
References
M. D. Mashkovskii, Medicinal Agents [in Russian], Vol. 2, 12th Ed., Meditsina, Moscow (1988).
A. S. Minina, G. M. Sorokoumova, A. A. Selishcheva, et al., Biofizika, 49(4), 674–679 (2004).
G. K. Khuller, M. Kapur, and S. Sharma, Curr. Pharm. Des., 10(26), 3263–3274 (2004).
R. T. Mehta, A. Keyhani, T. J. McQueen, et al., Antimicrob. Agents Chemother., 37(12), 2584–2587 (1993).
P. Deol and G. K. Khuller, Biochem. Biophys. Acta, 1334, 161–172 (1997).
A. Agarwal, H. Kandpal, H. P. Gupta, et al., Antimicrob. Agents Chemother., 38(3), 588–593 (1994).
B. Mohan, N. Sharda, and S. Singh, J. Pharm. Biomed. Anal., 31(3), 607–612 (2003).
G. G. Gallo and P. Radaelli, Anal. Profiles Drug Subst., 5, 467–513 (1976).
N. Maggi, S. Furesz, R. Pallanza, et al., Fortschr. Arzneimittelforsch., 19(4), 651–654 (1969).
V. I. Golyshevskaya, A. A. Selishcheva, L. P. Martynova, et al., Problems of Tuberculosis [in Russian], (2006).
I. M. Bushmakina, M. A. Martynova, and S. V. Konev, Dokl. Nats. Akad. Nauk Belarusi, 48(5), 70–72 (2004).
N. Maggi, R. Pallanza, and P. Sensi, Antimicrob. Agents Chemother., 5, 765–769 (1965).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 10, pp. 35–38, October, 2008.
Rights and permissions
About this article
Cite this article
Sorokoumova, G.M., Vostrikov, V.V., Selishcheva, A.A. et al. Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition. Pharm Chem J 42, 475–478 (2008). https://doi.org/10.1007/s11094-008-0153-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-008-0153-3