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GC/MS analysis of aqueous ethanol solutions of drugs. Part 1. Menthol and p-aminobenzoic acid derivatives

  • Structure of Chemical Compounds, Methods of Analysis and Process Control
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Pharmaceutical Chemistry Journal Aims and scope

Ajoint GC/MS analysis of aqueous and aqueous-ethanol solutions of some drugs including menthol, validol, benzocaine, novocaine, and menovazin has been performed using a Varian 3900/2100T (USA) instrument equipped with a Varian Factor Four VF-5ms capillary column. The structures of some impurities that were previously based on theoretical considerations are confirmed. Structural-analytical possibilities of the latest modification of the Varian GC/MS system with an ion-trap source are investigated. It is possible to obtain clear mass spectra even for low-intensity and partly overlapping chromatographic peaks using the given device combination. The results can be used for quality control of drugs based on the investigated compounds.

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Authors and Affiliations

  1. Center for Instrumental Methods and Innovative Analytical Techniques and Materials, Peoples Friendship University, Moscow, Russia

    A. I. Ermakov, Yu. Yu. Khomyakov, L. P. Soshenko & V. G. Plyushchikov

Authors
  1. A. I. Ermakov
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  2. Yu. Yu. Khomyakov
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  3. L. P. Soshenko
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  4. V. G. Plyushchikov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 8, pp. 53 – 56, August, 2009.

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Ermakov, A.I., Khomyakov, Y.Y., Soshenko, L.P. et al. GC/MS analysis of aqueous ethanol solutions of drugs. Part 1. Menthol and p-aminobenzoic acid derivatives. Pharm Chem J 43, 480–483 (2009). https://doi.org/10.1007/s11094-009-0328-6

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  • DOI: https://doi.org/10.1007/s11094-009-0328-6

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