The aim of the present study was to develop astaxanthin ester nanoemulsions with phosphatidylcholine and evaluate their stability during storage under various conditions. Monoesters were obtained by column chromatography of an oil extract of Haematococcus pluvialis and mixed astaxanthin esters. Monoester fatty-acid compositions were determined by HPLC. A solution of astaxanthin monoesters or a mixture of astaxanthin mono- and diesters in 5% aqueous EtOH was rapidly degraded in light at room temperature. The addition of antioxidants such as ascorbic acid and butylated hydroxytoluene did not give significant positive results. In contrast, simultaneous addition of albumin, which was used for these purposes for the first time, increased significantly the shelf life. The optimized conditions for producing nanoemulsions from astaxanthin esters and phosphatidylcholine by injection gave nanoemulsions with an average particle size of 50 nm that remained physically and chemically stable during storage for a month.
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References
Y. Lemoine and B. Schoefs, Photosynth. Res., 106(1 – 2), 155 – 177 (2010).
R. R. Ambati, S. M. Phang, S. Ravi, et al., Mar. Drugs, 12(1), 128 – 152 (2014).
Y. M. Naguib, J. Agric. Food Chem., 48(4), 1150 – 1154 (2000).
C. H. Chiu, C. C. Chang, S. T. Lin, et al., Int. J. Mol. Sci., 17(7), 1128 (2016).
A. R. Rao, R. Sarada, and G. A. Ravishankar, J. Sci. Food Agric., 87(6), 957 – 965 (2007).
J. P. Yuan, J. Peng, K. Yin, et al., Mol. Nutr. Food Res., 55(1), 150 – 165 (2011).
A. Bustamante, L. Masson, J. Velasco, et al., Food Chem., 190, 1013 – 1021 (2016).
S. N. Naess, H. R. Sliwka, V. Partali, et al., Chem. Phys. Lipids, 148(2), 63 – 69 (2007).
N. Khalid, G. Shu, I. Kobayashi, et al., Colloids Surf., B, 157, 355 – 365 (2017).
D. Sotomayor-Gerding, B. D. Oomah, F. Acevedo, et al., Food Chem., 199, 463 – 470 (2016).
M. M. M. Affandi, T. Julianto, and A. Majeed, Asian J. Pharm. Clin. Res., 4(1), 142 – 148 (2011).
Q. Zhou, J. Xu, S. Yang, et al., J. Oleo Sci., 14264, 1 – 11 (2015).
P. Gentine, A. Bubel, C. Crucifix, et al., J. Liposome Res., 22(1), 18 – 30 (2012).
Y. Weesepoel, H. Gruppen, W. de Bruijn, et al., J. Agric. Food Chem., 62(42), 10254 – 10263 (2014).
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The work was financed by Scientific ResearchWork, Order No. 1363 of June 25, 2019, for NRC Kurchatov Institute.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 8, pp. 18 – 22, August, 2020.
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Kulikova, I.S., Lotosh, N.Y., Turanova, V.A. et al. Stabilized Nanoemulsions of Astaxanthin Esters of Known Fatty-Acid Composition. Pharm Chem J 54, 811–815 (2020). https://doi.org/10.1007/s11094-020-02279-8
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DOI: https://doi.org/10.1007/s11094-020-02279-8