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Long Circulating Poly(Ethylene Glycol)-Decorated Lipid Nanocapsules Deliver Docetaxel to Solid Tumors

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Purpose

The purpose of this study was to evaluate the ability of poly(ethylene glycol)-coated lipid nanocapsules (LN) to deliver the highly potent hydrophobic anticancer drug docetaxel to solid tumors.

Methods

Docetaxel-loaded nanocapsules (80–120 nm) were produced by a solvent-free phase inversion process and were coated with polyethylene glycol distearoylphosphatidylethanolamine conjugate by a postinsertion step. In vivo studies were conducted in mice bearing subcutaneously implanted C26 colon adenocarcinoma to assess the pharmacokinetics and biodistribution of both the drug and LN.

Results

Incorporation of docetaxel into the LN dramatically increased the drug's biological half-life while providing substantial accumulation at the tumoral site. The pharmacokinetics and biodistribution pattern were found to depend on the specific surface area and shell composition of the nanocapsules.

Conclusion

This study demonstrates that docetaxel physically entrapped into a lipid colloidal drug carrier can be efficiently targeted to neoplastic tissues.

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Acknowledgment

The Canada Research Chair program is acknowledged for financial support.

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Authors and Affiliations

  1. Canada Research Chair in Drug Delivery, Faculty of Pharmacy, University of Montreal, C.P. 6128 Succ, Centre-ville, Montreal, (QC), H3C 3J7, Canada

    Mohamed Nabil Khalid, Pierre Simard, Alice Dragomir & Jean-Christophe Leroux

  2. Ethypharm Inc., 200 boul. Armand Frappier, Laval, (QC), H7V4A6, Canada

    Didier Hoarau

Authors
  1. Mohamed Nabil Khalid
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  2. Pierre Simard
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  3. Didier Hoarau
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  4. Alice Dragomir
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  5. Jean-Christophe Leroux
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Correspondence to Jean-Christophe Leroux.

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Khalid, M.N., Simard, P., Hoarau, D. et al. Long Circulating Poly(Ethylene Glycol)-Decorated Lipid Nanocapsules Deliver Docetaxel to Solid Tumors. Pharm Res 23, 752–758 (2006). https://doi.org/10.1007/s11095-006-9662-5

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  • DOI: https://doi.org/10.1007/s11095-006-9662-5

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