Abstract
A series of 6,7-dihydro-[1,2,4]triazolo[5,1-b]quinazolin-8(5H)-ones, 4a–o were synthesized via a one-pot, multicomponent reaction in the presence of water as a solvent under microwave irradiation using ceric ammonium nitrate as an oxidizing agent. This techno-chemical method provides a rapid construction of higher molecules in short duration with high yield. The adopted method was carried out in the presence of water without catalyst and yielded the compounds without any side products, and thus further purification of compounds by column chromatography was not required. All the synthesized compounds, 4a–o were screened for their 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity. All the compounds, 4a–o possessed moderate antioxidant activity when compared to their standard antioxidant (ascorbic acid).
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Acknowledgments
One of the authors, Dr. S. Mohana Roopan, thanks DST-FTYS Fast Track (No. SB/FT/CS-126/2012), Government of India, New Delhi, for providing the research grants. The authors wish to express their gratitude to SIF, VIT University, for NMR support. The other author, Mr. Rajesh Sompalle, wishes to thank the VIT University Management for providing RA fellowship and the infrastructure. Finally, we also thank Dr. G. Madhumitha, Assistant Professor, School of Advanced Sciences, VIT University, for granting access to the microwave instrumentation.
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Sompalle, R., Roopan, S.M. Microwave assisted synthesis of ring junction heterocyclic antioxidants. Res Chem Intermed 42, 5353–5366 (2016). https://doi.org/10.1007/s11164-015-2371-0
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DOI: https://doi.org/10.1007/s11164-015-2371-0