Abstract
One-pot, three-component condensation reaction between (phenylsulfonyl)acetonitrile, aromatic aldehydes, and α-naphthol for preparation of 4-(aryl)-3-(phenylsulfonyl)-4H-benzo[h]chromen-2-amine derivatives has been reported. The method involves domino Knoevenagel condensation/Michael addition, and cyclization cascade. The reaction was performed in glycerol, which is a commercially available, inexpensive and non-toxic compound. High purity of the products, very high yields and wide scope of substrates are advantages of this protocol.
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We gratefully appreciate the University of Sistan and Baluchestan Research Councils for the financial support of this work.
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Morshedi, A., Shaterian, H.R. Green approach to synthesis of novel and broad-range diversity of 4-(aryl)-3-(phenylsulfonyl)-4H-benzo[h]chromen-2-amine derivatives. Res Chem Intermed 44, 7219–7230 (2018). https://doi.org/10.1007/s11164-018-3552-4
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DOI: https://doi.org/10.1007/s11164-018-3552-4