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Formation and pharmacological activity of silicon—chitosan-containing glycerohydrogels obtained by biomimetic mineralization

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Abstract

The biomimetic sol—gel synthesis of silicon—chitosan-containing glycerohydrogels was carried out using silicon tetraglycerolate as a precursor. It was found that chitosan accelerates gel formation in weakly acidic media. In more acidic media, the kinetics of the process changes according to the curve with a maximum, which can be attributed to different mechanisms of silanol condensation before and after the isoelectric point. The investigated silicon—chitosan-containing glycerohydrogels exhibit antibacterial, anti-inflammatory, and wound healing activity. The synthesized hybrid glycerohydrogels are promising materials for biomedical applications.

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References

  1. H. Ehrlich, D. Janussen, P. Simon, V. Bazhenov, N. Shapkin, C. Erler, M. Mertig, R. Born, S. Heinemann, T. Hanke, H. Worch, J. Vournakis, J. Nanomaterials, 2008, doi:10.1155/2008/670235.

  2. M. Sumper, E. Brunner, ChemBioChem, 2008, 9, 1187.

    Article  CAS  Google Scholar 

  3. K. Spinde, M. Kammer, K. Freyer, H. Ehrlich, J. N. Vournakis, E. Brunner, Chem. Mater., 2011, 23, 2973.

    Article  CAS  Google Scholar 

  4. M. Wysokowki, T. Behm, R. Born, V. V. Bazhenov, H. Meißner, G. Richter, K. Szwarc-Rzepka, A. Makarova, D. Vyalikh, P. Schupp, T. Jesionowski, H. Ehrlich, Mater. Sci. Eng. C, 2013, 33, 3935.

    Article  Google Scholar 

  5. T. Coradin, R. Brayner, C. Gautier, M. Hemadi1, P. J. Lopez, J. Livage, Editorial Universitaria S.A., 2007, 419.

  6. Y. A. Shchipunov, T. Yu. Karpenko, Langmuir, 2004, 20, 3882.

    Article  CAS  Google Scholar 

  7. Y. A. Shchipunov, T. Yu. Karpenko, A. V. Krekoten, I. V. Postnova, J. Colloid Interface Sci., 2005, 287, 373.

    Article  CAS  Google Scholar 

  8. V. Pedroni, P. C. Schulz, M. E. Gschaider de Ferreira, M. A. Morini, Colloid Polym. Sci., 2000, 278, 964.

    Article  CAS  Google Scholar 

  9. K. Madhumathi, P. T. S. Kumar, K. C. Kavya, T. Furuike, H. Tamura, S. V. Nair, R. Jayakumar, Int. J. Biol. Macromol., 2009, 45, 289.

    Article  CAS  Google Scholar 

  10. G. J. Copello, A. M. Mebert, M. Raineri, M. P. Pesentia, L. E. Diaz, J. Hazard. Mater., 2011, 186, 932.

    Article  CAS  Google Scholar 

  11. Khitozan [Chitosan], Eds K. G. Skryabin, S. N. Mikhailov, and V. P. Varlamov, Center "Bioinzheneriya" of the Russian Academy of Sciences, Moscow, 2013, 591 pp. (in Russian).

  12. M. N. V. Ravi Kumar, R. A. A. Muzzarelli, C. Muzzarelli, A. J. Domb, Chem. Rev., 2004, 104, 6017.

    Article  Google Scholar 

  13. I. Gill, A. Ballesteros, J. Am. Chem. Soc., 1998, 120, 8587.

    Article  CAS  Google Scholar 

  14. T. G. Khonina, O. N. Chupakhin, L. P. Larionov, T. G. Boyakovskaya, A. L. Suvorov, E. V. Shadrina, Pharm. Chem. J. (Engl. Transl.), 2008, 11, No. 42, 609 [Khim.-Farm. Zh., 2008, 11, 5].

    Article  Google Scholar 

  15. T. G. Khonina, E. V. Shadrina, A. A. Boiko, O. N. Chupakhin, L. P. Larionov, A. A. Volkov, V. D. Burda, Russ. Chem. Bull. (Int. Ed.), 2010, 59, 75 [Izv. Akad. Nauk, Ser. Khim., 2010, 76].

    Article  CAS  Google Scholar 

  16. T. G. Khonina, A. P. Safronov, E. V. Shadrina, M. V. Ivanenko, A. I. Suvorova, O. N. Chupakhin, J. Colloid Interface Sci., 2012, 365, 81.

    Article  CAS  Google Scholar 

  17. E. Yu. Larchenko, T. G. Khonina, O. N. Chupakhin, L. P. Larionov, Perspektivnye Materialy [Perspective Materials], 2011, 13, 978 (in Russian).

    Google Scholar 

  18. E. Y. Larchenko, E. V. Shadrina, T. G. Khonina, O. N. Chupakhin, Mendeleev Commun., 2014, 24, 201.

    Article  CAS  Google Scholar 

  19. E. Yu. Larchenko, T. G. Khonina, E. V. Shadrina, A. V. Pestov, O. N. Chupakhin, N. V. Men´shutina, A. E. Lebedev, D. D. Lovskaya, L. P. Larionov, S. A. Chigvintsev, Russ. Chem. Bull. (Int. Ed.), 2014, 63, 1225–1231 [Izv. Akad. Nauk, Ser. Khim., 2014, 1225].

    Article  Google Scholar 

  20. Yu. Shchipunov, N. Ivanova, V. Silant´ev, Green Chem., 2009, 11, 1758.

    Article  CAS  Google Scholar 

  21. Yu. A. Shchipunov, N. A. Ivanova, S. A. Sarin, Mendeleev Commun., 2009, 19, 149.

    Article  CAS  Google Scholar 

  22. E. Brunner, K. Lutz, M. Sumper, Phys. Chem. Chem. Phys., 2004, 6, 854.

    Article  CAS  Google Scholar 

  23. O. Helmecke, A. Hirsch, P. Behrens, H. Menzel, J. Colloid Interface Sci., 2008, 321, 44.

    Article  CAS  Google Scholar 

  24. D. Brandhuber, V. Torma, C. Raab, H. Peterlik, A. Kulak, N. Hüsing, Mater. Chem., 2005, 17, 4262.

    Article  CAS  Google Scholar 

  25. A. C. Pierre, Introduction to Sol—Gel Processing, Kluwer, Boston, 1998, 394 pp.

    Book  Google Scholar 

  26. J. Livage, M. Henry, C. Sanchez, Prog. Solid State Chem., 1988, 18, 259.

    Article  CAS  Google Scholar 

  27. O. N. Chupakhin, A. N. Bondarev, I. N. Shtan´ko, T. G. Khonina, E. V. Shadrina, E. A. Bogdanova, L. P. Larionov, Russ. Chem. Bull. (Int. Ed.), 2014, 63, 1219–1224 [Izv. Akad. Nauk, Ser. Khim., 2014, 1219].

    Article  CAS  Google Scholar 

  28. R. Muzzarelli, Mar. Drugs, 2010, 8, 292.

    Article  CAS  Google Scholar 

  29. A. B. Shipovskaya, D. A. Rudenko, V. I. Fomina, N. V. Ostrovsky, Eur. J. Natural History, 2012, 6, 7.

    Google Scholar 

  30. I. Younes, S. Sellimi, M. Rinaudo, K. Jellouli, M. Nasri, Int. J. Food Microbiology, 2014, 185, 57.

    Article  CAS  Google Scholar 

  31. A. I. Gamzazade, V. M. Slimak, A. M. Sklar, E. V. Shtikova, S. V. Pavlova, S. V. Rogojin, Acta Polymerica, 1985, 36, No. 8, 420.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 ul. S. Kovalevskoi, 620137, Ekaterinburg, Russian Federation

    E. V. Shadrina, T. G. Khonina & E. Yu. Larchenko

  2. N. G. Chernyshevsky Saratov State University, 83 ul. Astrakhanskaya, 410012, Saratov, Russian Federation

    O. N. Malinkina, A. B. Shipovskaya & V. I. Fomina

  3. Ural State Medical University, 3 ul. Repina, 620219, Ekaterinburg, Russian Federation

    N. A. Popova, I. G. Zyryanova & L. P. Larionov

Authors
  1. E. V. Shadrina
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  2. O. N. Malinkina
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  3. T. G. Khonina
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  4. A. B. Shipovskaya
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  5. V. I. Fomina
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  6. E. Yu. Larchenko
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  7. N. A. Popova
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  8. I. G. Zyryanova
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  9. L. P. Larionov
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Corresponding author

Correspondence to T. G. Khonina.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1633–1639, July, 2015.

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Shadrina, E.V., Malinkina, O.N., Khonina, T.G. et al. Formation and pharmacological activity of silicon—chitosan-containing glycerohydrogels obtained by biomimetic mineralization. Russ Chem Bull 64, 1633–1639 (2015). https://doi.org/10.1007/s11172-015-1053-9

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  • DOI: https://doi.org/10.1007/s11172-015-1053-9

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