Abstract
Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga3+ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga3+ complex with the fully deprotonated DOTMP ligand, lg KML equal to 27.8, is higher than the corresponding constant for the Ga3+ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga3+ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2184–2187, December, 2018.
Based on the materials of the VII International Conference on Physical Chemistry of Crown Compounds, Porphyrins and Phthalocyanines (September 9–14, 2018, Tuapse, Russia).
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Tsebrikova, G.S., Barsamian, R.T., Solov´ev, V.P. et al. Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid). Russ Chem Bull 67, 2184–2187 (2018). https://doi.org/10.1007/s11172-018-2352-8
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DOI: https://doi.org/10.1007/s11172-018-2352-8