Abstract
The effect of mutation CycB 2g on mitosis in neural ganglia and imaginal disks was studied in third-instar larvae of Drosophila melanogaster. Chromosome condensation and segregation were shown to be impaired in dividing cells of mutant larvae. During the three-year period of maintenance of the mutation in heterozygote, frequencies of some defects decreased via cellular adaptive modification.
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REFERENCES
Modrich, P., DNA Mismatch Correction, Annu. Rev. Bio-chem., 1987, vol. 56, pp. 435–466.
Wassmann, K. and Benezra, R., Mitotic Checkpoints: From Yeast to Cancer, Curr. Opin. Gen. Dev., 2001, vol. 11, pp. 83–90.
Vel’kov, V.V., New Insights into the Molecular Mechanisms of Evolution: Stress Increases Genetic Diversity, Mol. Biol. (Moscow), 2002, vol. 36, pp. 277–285.
Guidebook to the Cytoskeletal and Motor Proteins, Kreis, T. and Vale, R., Eds., New York: Oxford Univ. Press, 1999, 2nd ed.
Lebedeva, L.I., Trunova, S.A., and Omelyanchuk, L.V., Genetic Control of Mitosis: The Modified Adaptive Expression of the v158 Mutation, Rus. J. Genet., 2000, vol. 36, no.10, pp. 1130–1135.
Sekelsky, J.J., McKim, K.S., Messina, L., et al., Identification of Novel Meiotic Genes Recovered in a P-Element Screen, Genetics, 1999, vol. 152, pp. 529–542.
Cairns, J., Overbough, J., and Miller, S., The Origin of Mutations, Nature, 1988, vol. 335, pp. 142–145.
Jacobs, H.W., Knoblich, J.A., and Lehner, C.F., Drosophila Cyclin B3 Is Required for Female Fertility and Is Dispensable for Mitosis Like Cyclin B, Genes Dev., 1998, vol. 12, pp. 3741–3751.
Parry, D.H. and O’Farrell, P.H., The Schedule of Destruction of Three Mitotic Cyclins Can Dictate the Timings of Events from Mitosis, Curr. Biol., 2001, vol. 11, pp. 671–683.
Omelyanchuk, L.V., Volkova, E.I., and Fedorova, S.A., Characterization of Insertion Mutations Leading to Mitosis Abnormalities in Drosophila melanogaster by Means of the Reporter Gene-Containing Transposon, Rus. J. Genet., 1997, vol. 33, no.11, pp. 1279–1285.
Lehner, C.F. and O’Farrell, P.H., The Role of Drosophila Cyclins A and B in Mitotic Control, Cell (Cambridge, Mass.), 1990, vol. 61, pp. 535–547.
Trunova, S.A., Gur’ev, V.P., Lebedeva, L.I., et al., Tissue Specificity of Cyclin B Expression, Dokl. Akad. Nauk SSSR, 1998, vol. 361, pp. 839–842.
Lebedeva, L.I. and Fedorova, S.A., Genetic Control of Mitosis: Is the Protein MASTv40 an Element of the Check Points System, Rus. J. Genet., 2004, vol. 40, no.4, pp. 387–392.
Jackman, M.R. and Pines, J.N., Cyclins and G2/M Transition, Checkpoint Control and Cancer, Kastan, M.B., Ed., Cold Spring Harbor, New York: Cold Spring Harbor Lab., 1997, vol. 29, pp. 47–74.
Verde, F., Dogterom, M., Stezier, E., et al., Control of Microtubule Dynamics and Length by Cyclin A-Dependent and Cyclin B-Dependent Kinases in Xenopus egg Extracts, J. Cell Biol., 1992, vol. 118, pp. 1097–1108.
Hirano, T., The ABCs of SMC Proteins: Two-Armed ATPases for Chromosome Condensation, Cohesion, and Repair, Genes Dev., 2002, vol. 16, pp. 399–414.
Hohmann, P., Phosphorylation of H1 Histones, Mol. Cell Biochem., 1983, vol. 57, pp. 81–92.
Krystal, G.W. and Poccia, D.L., Phosphorylation of Cleavage Stage Histone H1 in Mitotic and Premature Condensed Chromosomes, Exp. Cell Res., 1981, vol. 134, pp. 41–48.
Terada, Y., Role of Chromosomal Passenger in Chromosome Segregation and Cytokinesis, Cell Struct. Funct., 2001, vol. 26, pp. 653–657.
Parry, D.H., Hickson, G.R., and O’Farrell, P.H., Cyclin B Destruction Triggers Changes in Kinetochore Behavior Essential for Successful Anaphase, Curr. Biol., 2003, vol. 13, pp. 647–653.
Uemura, T., Ohkuea, H., Adachi, Y., et al., DNA Topoisomerase II Is Required for Condensation and Separation of Mitotic Chromosomes in S. pombe, Cell (Cambridge, Mass.), 1987, vol. 50, pp. 917–925.
Giet, R. and Glover, D.M., Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and Organize the Central Spindle during Cytokinesis, J. Cell Biol., 2001, vol. 152, pp. 669–682.
Ohtsubo, M., Okazahi, H., and Nishimoto, T., The RCCI Protein, a Regulator for the Onset of Chromosome Condensation, Locates in the Nucleus and Binds to DNA, J. Cell Biol., 1989, vol. 109, pp. 1389–1397.
Lebedeva, L.I., Trunova, S.A., Fedorova, S.A., and Omelyanchuk, L.V., Genetic Control of Mitosis: Features of Anaphase Separation of Sister Chromatid Sets in Mutant Strain aar v158, Rus. J. Genet., 2003, vol. 9, no.9, pp. 1021–1028.
Lebedeva, L.I., Fedorova, S.A., and Omelyanchuk, L.V., genetic Control of Mitosis: Mutation ff3 Causes Premature Beginning of Telophase and Chromatin Reorganization in Drosophila melanogaster, Rus. J. Genet., 2003, vol. 39, no.7, pp. 784–790.
Tomkiel, J.E. and Eadnshaw, W.C., Structure of Mammalian Centromere, Chromosome Segregation and Aneuploidy, Vig, B.K., Ed., Berlin: Springer-Verlag, 1993, pp. 13–29.
Liao, H., Li, G., and Yen, T.J., Mitotic Regulation of Microtubule Cross-Linking Activity of CENP-E Kinetochore Protein, Science, 1994, vol. 265, pp. 394–398.
Tomkiel, J.E., Cooke, C.A., Saiton, H., et al., CENP-E Is Required for Maintaining Proper Kinetochore Size and for a Timely Transition to Anaphase, J. Cell Biol., 1994, vol. 125, pp. 531–545.
Schmalhausen, I.I., Faktory evolyutsii (Factors of Evolution), Moscow: Nauka, 1968.
Tsuji, H. and Tobari, I., Effects of 5-Bromodeoxyuridine on Metamorphosis and on Cell Cycle in Drosophila melanogaster, Exp. Cell Res., 1980, vol. 125, pp. 79–85.
Milan, M., Compuzano, S., and Garcia-Bellido, A., Cell Cycling and Patterned Cell Proliferation in the Wing Primordium of Drosophila, Proc. Natl. Acad. Sci. USA, 1996, vol. 93, pp. 640–645.
Latham, K.E., Mechanisms and Control of Embryonic Genome Activation in Mammalian Embryos, Int. Rev. Cytol., 1999, vol. 193, pp. 71–124.
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Translated from Genetika, Vol. 41, No. 3, 2005, pp. 312–319.
Original Russian Text Copyright © 2005 by Lebedeva, Trunova, Omelyanchuk.
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Lebedeva, L.I., Trunova, S.A. & Omelyanchuk, L.V. Genetics of the cell cycle: Adaptive modification of the CycB 2g mutation expression in dividing cells of Drosophila melanogaster . Russ J Genet 41, 237–243 (2005). https://doi.org/10.1007/s11177-005-0079-8
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DOI: https://doi.org/10.1007/s11177-005-0079-8