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Synthesis, characterization and anticancer activity of 3-aminopyrazine-2-carboxylic acid transition metal complexes

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Abstract

Synthetic procedures are described that allow access to the new complexes cis-[Mo2O5(apc)2], cis-[WO2(apc)2], trans-[UO2(apc)2], [Ru(apc)2(H2O)2], [Ru(PPh3)2(apc)2], [Rh(apc)3], [Rh(PPh3)2(apc)2]ClO4, [M(apc)2], [M(PPh3)2(apc)]Cl, [M(bpy)(apc)]Cl (M(II) = Pd, Pt), [Pd(bpy)(apc)Cl], [Ag(apc)(H2O)2] and [Ir(bpy)(Hapc)2]Cl3, where Hapc, is 3-aminopyrazine-2-carboxylic acid. These complexes were characterized by physico-chemical and spectroscopic techniques. Both Hapc and several of its complexes display significant anticancer activity against Ehrlich ascites tumour cells (EAC) in albino mice.

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Acknowledgements

We wish to thank Prof. F. Badria (Liver Lab., Faculty of Pharmacy, Mansoura University, Egypt) for his assistance in the anticancerous measurements and Dr. A. Atwan (FRCSed) for the valuable discussion of this section.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

    Issam M. Gabr, Hala A. El-Asmy, Mohamed S. Emmam & Sahar I. Mostafa

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  1. Issam M. Gabr
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  2. Hala A. El-Asmy
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  3. Mohamed S. Emmam
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  4. Sahar I. Mostafa
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Correspondence to Sahar I. Mostafa.

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Gabr, I.M., El-Asmy, H.A., Emmam, M.S. et al. Synthesis, characterization and anticancer activity of 3-aminopyrazine-2-carboxylic acid transition metal complexes. Transition Met Chem 34, 409–418 (2009). https://doi.org/10.1007/s11243-009-9210-3

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  • DOI: https://doi.org/10.1007/s11243-009-9210-3

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