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Studies on the interactions of polymer-anchored copper(II) complexes with tRNA

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Abstract

The binding interactions between tRNA and polyethyleneimine-anchored copper(II) complexes with 1,10-phenanthroline and 2,2′-bipyridine ligands and varying degrees of coordination have been studied using physico-chemical techniques. In both sets of polyethyleneimine-anchored complexes, the complexes with higher degree of coordination bind more strongly to tRNA than those with lower degree of coordination. Binding to tRNA appears to be mainly electrostatic in nature.

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References

  1. Qingxiang W, Wenqu L, Feng G, Shunxing L, Jiancong N, Zhouyan Z (2010) Polyhedron 29:539–543

    Article  Google Scholar 

  2. YanZi M, HongJu U, Ke-Zhi W (2009) J Phys Chem B 113:11039–11047

    Article  Google Scholar 

  3. Gravina A, Pasina A, Pinciroli E, Micheloni AM, Zunino F (1989) Inorg Chim Acta 157:165–166

    Article  CAS  Google Scholar 

  4. Onfelt B, Lincoln P, Norden B (2001) J Am Chem Soc 123:3630–3637

    Article  CAS  Google Scholar 

  5. Banville DL, Marzilli LG, Wilson WD (1983) Biochem Biophys Res Commun 113:148–154

    Article  CAS  Google Scholar 

  6. Carvlin MJ, Gupta NRD, Fiel J (1982) Biochem Biophys Res Commun 108:66–73

    Article  CAS  Google Scholar 

  7. Kelly JM, Murphy MJ, McConnel DJ, OhUigin C (1985) Nucleic Acids Res 13:167–184

    Article  CAS  Google Scholar 

  8. Dougherty G, Pilbrow JR, Skorobogaty A, Smith TD (1985) J Chem Soc Faraday Trans 81:1739–1743

    Article  CAS  Google Scholar 

  9. Schneider JH, Odo J, Nakamoto K (1988) Nucleic Acids Res 16:10323–10338

    Article  CAS  Google Scholar 

  10. Jennette KW, Lippard SJ, Vassiliades GA, Baner WR (1974) Proc Natl Acad Sci USA 71:3839–3843

    Article  CAS  Google Scholar 

  11. Barton JK (1986) Science 233:727–734

    Article  CAS  Google Scholar 

  12. Chu F, Smith J, Lynch VM, Anslyn EV (1995) Inorg Chem 34:5689–5690

    Article  CAS  Google Scholar 

  13. Lim AS, Barton JK (1998) Biochemistry 37:9138–9146

    Article  CAS  Google Scholar 

  14. Carter PJ, Cheng CC, Thorp HH (1998) J Am Chem Soc 120:632–642

    Article  CAS  Google Scholar 

  15. Chow CS, Barton JK (1992) Biochemistry 31:5423–5429

    Article  CAS  Google Scholar 

  16. Mei WJ, Wei XY (2007) Transition Met Chem 32:685–688

    Article  CAS  Google Scholar 

  17. Xu H, Deng H, Zhang QL, Huang Y, Liu JZ, Ji LN (2003) Inorg Chem Commun 6:766–768

    Article  CAS  Google Scholar 

  18. Ismal MdM, Pandya P, Chowdhury SR, Kumar S, Kumar GS (2008) J Mol Struct 891:498–507

    Article  Google Scholar 

  19. Ghazaryan AA, Dalyan YB, Haroutiunian SG, Tikhomirova A, Taulier N, Wells JW, Chalikian TV (2006) J Am Chem Soc 128:1914–1921

    Article  CAS  Google Scholar 

  20. Hermann T, Westhof E (2000) Comb Chem High Throughput Screen 3:219–234

    CAS  Google Scholar 

  21. Vicens Q, Westhof E (2003) Biopolymers 70:42–57

    Article  CAS  Google Scholar 

  22. Saiz MF, Werner F, Davis TM, Schneider HJ, Wilson WD (2002) Eur J Org Chem 2002:1077–1084

    Article  Google Scholar 

  23. Schechter B, Arnon R, Wilchek M (1995) React Polym 25:167–175

    Article  CAS  Google Scholar 

  24. Boletta A, Benigni A, Lutz J, Remuzzi G, Soria MR, Monaco L (1997) Hum Gene Ther 8:1243–1251

    Article  CAS  Google Scholar 

  25. Kren BT, Bandyopadhyay P, Steer CJ (1998) Nat Med 4:285–290

    Article  CAS  Google Scholar 

  26. Bandyopadhyay P, Ma X, Stieers CL, Kren BT, Steer CJ (1999) J Biol Chem 274:10163–10197

    Article  CAS  Google Scholar 

  27. Kumar RS, Sasikala K, Arunachalam S (2008) J Inorg Biochem 102:234–241

    Article  CAS  Google Scholar 

  28. Kumar RS, Arunachalam S, Periasamy VS, Preethy CP, Riyasdeen A, Akbarsha MA (2008) Eur J Med Chem 43:2082–2091

    Article  CAS  Google Scholar 

  29. Watson RT, Desai N, Wildsmith J, Wheeler JF, Kane Magurie NAP (1999) Inorg Chem 38:2683–2687

    Article  CAS  Google Scholar 

  30. Vijayalakshmi R, Kanthimathi M, Subramanian V, Nair BU (2000) Biochim Biophys Acta 1475:157–162

    CAS  Google Scholar 

  31. Wolfe A, Shimer GH, Meehan DT (1987) Biochemistry 26:6392–6396

    Article  CAS  Google Scholar 

  32. Liu C, Zhou J, Xu H (1998) J Inorg Biochem 7:1–6

    Article  Google Scholar 

  33. Antony T, Atreyi M, Rao MVR (1995) Chem Biol Interact 97:199–214

    Article  CAS  Google Scholar 

  34. Zama M, Ichimura S (1976) Biopolymers 15:1693–1699

    Article  CAS  Google Scholar 

Download references

Acknowledgments

We are grateful to the University Grants Commission–Special Assistance Programme & COSIST and Department of Science and Technology and Fund for Improvement of S&T infrastructure programmes of the School of Chemistry, Bharathidasan University, and Research Schemes by Council of Scientific and Industrial Research (Grant No. 01(2075)/06/EMR-II) and University Grants Commission (Grant No. F. 32-274/2006), New Delhi, sanctioned to one of the authors, S.A. We express sincere thanks to Prof. PR. Athappan, Department of Inorganic Chemistry, Madurai Kamaraj University, Madurai, for CD studies.

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  1. School of Chemistry, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India

    Jagadeesan Lakshmipraba & Sankaralingam Arunachalam

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  1. Jagadeesan Lakshmipraba
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  2. Sankaralingam Arunachalam
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Correspondence to Sankaralingam Arunachalam.

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Lakshmipraba, J., Arunachalam, S. Studies on the interactions of polymer-anchored copper(II) complexes with tRNA. Transition Met Chem 35, 477–482 (2010). https://doi.org/10.1007/s11243-010-9352-3

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  • DOI: https://doi.org/10.1007/s11243-010-9352-3

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