Skip to main content

Advertisement

SpringerLink
Log in

Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer

  • Urology - Original Paper
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Objectives

The objective of this study was to investigate and characterize the clinicopathological features of incidentally detected prostate cancer in radical cystoprostatectomy specimens from Japanese men with bladder cancer.

Materials and methods

We reviewed the pathological reports of 251 male patients who underwent radical cystoprostatectomy for bladder cancer at our institution and identified men with incidentally detected prostate cancer in these specimens. Clinicopathological data of patients with incidental prostate cancer in cystoprostatectomy specimens (group A) were compared with those of 193 patients with clinically detected prostate cancer who underwent radical prostatectomy (group B). Immunohistochemical staining was also performed to measure the expression levels of Ki-67, p53 and androgen receptor (AR) proteins in specimens from both groups A and B.

Results

In this series, a total of 31 patients (12.3%; group A) were incidentally diagnosed as having prostate cancer in radical cystoprostatectomy specimens. Clinically significant cancer, defined as any tumor greater than 0.5 cc according to the report by Stamy et al. (Cancer 71:933–938, 1993) was detected in 9 (29.0%) in group A and 170 (88.1%) in group B. Mean age in group A was significantly older than that in group B, while despite the lack of significant difference in the incidence of seminal vesicle invasion between these two groups, other parameters in group A were significantly more favorable than those in group B, including serum prostate-specific antigen, pathological stage, Gleason score, perineural invasion and capsular penetration. None of the patients in group A had biochemical recurrence (median observation period, 82 months); however, biochemical recurrence occurred in 41 (21.2%) in group B (median observation period, 46 months). Furthermore, immunohistochemical study demonstrated the significantly greater expression of Ki-67, p53 and AR proteins in group B than in group A.

Conclusions

Clinicopathological features of incidentally detected prostate cancer are markedly more favorable than those of clinically detected prostate cancer, which may reflect less aggressive biological phenotypes of incidental prostate cancer arising in Japanese men.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Quinn M, Babb P (2002) Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part II: individual countries. BJU Int 90:174–184. doi:10.1046/j.1464-410X.2002.02823.x

    Article  CAS  PubMed  Google Scholar 

  2. Scardino PT, Weaver R, Hudson MA (1992) Early detection of prostate cancer. Hum Pathol 23:211–222. doi:10.1016/0046-8177(92)90102-9

    Article  CAS  PubMed  Google Scholar 

  3. Abbas F, Hochberg D, Civantos F, Soloway M (1996) Incidental prostatic adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer. Eur Urol 30:322–326

    CAS  PubMed  Google Scholar 

  4. Montie JE, Wood DP Jr, Ponte JE, Boyett JM, Levin HS (1989) Adenocarcinoma of the prostate in cystoprostatectomy specimens removed for bladder cancer. Cancer 63:381–385. doi:10.1002/1097-0142(19890115)63:2<381::AID-CNCR2820630230>3.0.CO;2-O

    Article  CAS  PubMed  Google Scholar 

  5. Pritchett TR, Moreno J, Warner NE, Lieskovsky G, Nichols PW, Cook BA, Skinner DG (1988) Unsuspected prostatic adenocarcinoma in patients who have undergone radical cystoprostatectomy for transitional cell carcinoma of the bladder. J Urol 139:1214–1216

    CAS  PubMed  Google Scholar 

  6. Aydin O, Cosar EF, Varinli S, Bugdatci R, Tansung Z (1999) Prostatic intraepithelial neoplasia in prostate specimens: frequency, significance and relationship to the sampling of the specimen (a retrospective study of 121 cases). Int Urol Nephrol 31:687–697. doi:10.1023/A:1007120907921

    Article  CAS  PubMed  Google Scholar 

  7. Moutzouris G, Barbatis C, Plastiras D, Mertziotis N, Katsifotis C, Presvelos V, Theodorou C (1999) Incidence and histological findings of unsuspected prostatic adenocarcinoma in radical cystoprostatectomy for transitional cell carcinoma of the bladder. Scand J Urol Nephrol 33:27–30

    CAS  PubMed  Google Scholar 

  8. Conrad S, Hautmann SH, Henke RP, Erbersdobler A, Simon J, Straub M, Graefen M, Hautmann RE, Huland H (2001) Detection and characterization of early prostate cancer by six systematic biopsies and fine needle aspiration cytology in prostates from bladder cancer patients. Eur Urol 39:25–29. doi:10.1159/000052579

    Article  PubMed  Google Scholar 

  9. Cindolo L, Benincasa G, Autorino R, Domizio S, de Rosa G, Testa G, D’Armiento M, Altieri V (2001) Prevalence of silent prostatic adenocarcinoma in 165 patients undergone cystoprostatectomy: a retrospective study. Oncol Rep 8:269–271

    CAS  PubMed  Google Scholar 

  10. Prange W, Erbersdobler A, Hammerer P, Graefen M, Hautmann SH, Hautmann RE, Huland H, Henke RP (2001) High-grade prostatic intraepithelial neoplasia in cystoprostatectomy specimens. Eur Urol 39:30–31. doi:10.1159/000052580

    Article  PubMed  Google Scholar 

  11. Ward JF, Bartsch G, Sebo TJ, Pinggerra GM, Blute ML, Zincke H (2004) Pathologic characterization of prostate cancers with a very low serum prostate specific antigen (0–2 ng/ml) incidental to cystoprostatectomy: is PSA a useful indicator of clinical significance? Urol Oncol 22:40–47. doi:10.1016/S1078-1439(03)00093-0

    CAS  PubMed  Google Scholar 

  12. Revelo MP, Cookson MS, Chang SS, Shook MF, Smith JA Jr, Shappell SB (2004) Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: implications for possible apical sparing surgery. J Urol 171:646–651. doi:10.1097/01.ju.0000107380.40481.bc

    Article  PubMed  Google Scholar 

  13. Montironi R, Mazzucchelli R, Santinelli A, Scarpelli M, Lopez Beltran A, Bostwick DG (2005) Incidentally detected prostate cancer in cystoprostatectomies: pathological and morphometric comparison with clinically detected cancer in totally embedded specimens. Hum Pathol 36:646–654. doi:10.1016/j.humpath.2005.03.018

    Article  PubMed  Google Scholar 

  14. Ruffion A, Manel A, Massoud W, Decaussin M, Berger N, Paparel P, Morel-Journel N, Lopez JG, Champetier D, Devonec M, Perrin P (2005) Preservation of prostate during radical cystectomy: evaluation of prevalence of prostate cancer associated with bladder cancer. Urology 65:703–707. doi:10.1016/j.urology.2004.10.076

    Article  CAS  PubMed  Google Scholar 

  15. Delongchamps NB, Mao K, Theng H, Zerbib M, Debré B, Peyromaure M (2005) Outcome of patients with fortuitous prostate cancer after radical cystoprostatectomy for bladder cancer. Eur Urol 48:946–950. doi:10.1016/j.eururo.2005.07.008

    Article  PubMed  Google Scholar 

  16. Kouriefs C, Fazili T, Masood S, Naseem MS, Mufti GR (2005) Incidentally detected prostate cancer in cystoprostatectomy specimens. Urol Int 75:213–216. doi:10.1159/000087796

    Article  CAS  PubMed  Google Scholar 

  17. Lee SH, Chang PL, Chen SM, Sun GH, Chen CL, Shen BY, Wu YS, Tsui KH (2006) Synchronous primary carcinomas of the bladder and prostate. Asian J Urol 8:357–359

    Google Scholar 

  18. Rocco B, de Cobelli O, Leon ME, Ferruti M, Mastropasqua MG, Matei DV, Gazzano G, Verweij F, Scardino E, Musi G, Djavan B, Rocco F (2006) Sensitivity and detection rate of a 12-core trans-perineal prostate biopsy: preliminary report. Eur Urol 49:827–833. doi:10.1016/j.eururo.2005.12.021

    Article  PubMed  Google Scholar 

  19. Winkler MH, Livni N, Mannion EM, Hrouda D, Christmas T (2007) Characteristics of incidental prostatic adenocarcinoma in contemporary radical cystoprostatectomy specimens. BJU Int 99:554–558. doi:10.1111/j.1464-410X.2006.06660.x

    Article  PubMed  Google Scholar 

  20. Abdelhady M, Abusamra A, Pautler SE, Chin L, Izawa JI (2007) Clinically significant prostate cancer found incidentally in radical cystoprostatectomy specimens. BJU Int 99:326–329. doi:10.1111/j.1464-410X.2006.06558.x

    Article  PubMed  Google Scholar 

  21. Watanabe M, Nakayama T, Shiraishi T, Stemmermann GN, Yatani R (2000) Comparative studies of prostate cancer in Japan versus the United States. A review. Urol Oncol 5:274–283. doi:10.1016/S1078-1439(00)00092-2

    Article  PubMed  Google Scholar 

  22. Inoue T, Segawa T, Shiraishi T, Yoshida T, Toda Y, Yamada T, Kinukawa N, Kinoshita H, Kamoto T, Ogawa O (2005) Androgen receptor, Ki67, and p53 expression in radical prostatectomy specimens predict treatment failure in Japanese population. Urology 66:332–337. doi:10.1016/j.urology.2005.02.028

    Article  PubMed  Google Scholar 

  23. Sakai I, Harada K, Hara I, Eto H, Miyake H (2005) A comparison of the biological features between prostate cancers arising in the transition and peripheral zones. BJU Int 96:528–532. doi:10.1111/j.1464-410X.2005.05678.x

    Article  PubMed  Google Scholar 

  24. Stamey TA, Freiha FS, McNeal JE, Redwine EA, Whittemore AS, Schmid HP (1993) Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer. Cancer 71:933–938. doi:10.1002/1097-0142(19930201)71:3+<933::AID-CNCR2820711408>3.0.CO;2-L

    Article  CAS  PubMed  Google Scholar 

  25. Kurahashi T, Muramaki M, Yamanaka K, Hara I, Miyake H (2005) Expression of the secreted form of clustering protein in renal cell carcinoma as a predictor of disease extension. BJU Int 96:895–899. doi:10.1111/j.1464-410X.2005.05733.x

    Article  CAS  PubMed  Google Scholar 

  26. Zellweger T, Ninck C, Bloch M, Mirlacher M, Koivisto PA, Helin HJ, Mihatsch MJ, Gasser TC, Bubendorf L (2005) Expression patterns of potential therapeutic targets in prostate cancer. Int J Cancer 113:619–628. doi:10.1002/ijc.20615

    Article  CAS  PubMed  Google Scholar 

  27. Miyake H, Muramaki M, Kurahashi T, Takenaka A, Fujisawa M (2009) Expression of potential molecular markers in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy. Urol Oncol (in press)

Download references

Author information

Authors and Affiliations

  1. Division of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Toshifumi Kurahashi, Hideaki Miyake, Junya Furukawa, Masafumi Kumano, Atsushi Takenaka & Masato Fujisawa

Authors
  1. Toshifumi Kurahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hideaki Miyake
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Junya Furukawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masafumi Kumano
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Atsushi Takenaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masato Fujisawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hideaki Miyake.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kurahashi, T., Miyake, H., Furukawa, J. et al. Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer. Int Urol Nephrol 42, 73–79 (2010). https://doi.org/10.1007/s11255-009-9578-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-009-9578-1

Keywords

Search

Navigation