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Plasma Concentration of Insulin-like Growth Factor I (IGF-I) in Growing Ardenner Horses Suffering from Juvenile Digital Degenerative Osteoarthropathy

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Abstract

Degenerative osteoarthropathy resulting in a reduced active lifespan was observed in Ardenner horses. In the context of joint biology, insulin-like growth factor I (IGF-I) is a potential candidate to affect the anabolism of cartilage matrix molecules. A group of 30 Ardenner horses reared under standardized conditions from weaning were evaluated periodically from 15 to 28 months of age to detect the early manifestations of the disease. At the end of this period, horses were classified in two pathological groups related to the degree of interphalangeal degenerative osteoarthropathy based on clinical and radiographic evaluations: healthy (46.7%) and pathological (53.3%) horses. Seven sequential blood samples were taken from each horse (during the evaluation period) to study the variation of IGF-I plasma concentration. We tested the variations of the IGF-I plasma concentration during growth, and the effect of sex and of pathological classes. Significant variations were observed during the research period, with a maximum value corresponding to spring and a minimum in autumn. A significant reduction of the IGF-I plasma concentration was also observed in the pathological horses (433.5 ± 19.5 ng/ml) compared to the healthy horses (493.9 ± 18.2 ng/ml). An alteration in the level of this growth factor could induce a disregulation of the mechanisms involved in the local control of joint and bone tissue development.

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Abbreviations

ELISA:

enzyme-linked immunosorbent assay

IGF-I:

insulin-like growth factor I

IGFBP:

insuline-like growth factor binding protein

IL-I:

interleukin I

LSM:

least-squares mean

MDG:

mean daily gain

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Authors and Affiliations

  1. Centre Européen du Cheval, Mont-le-Soie, Vielsalm

    J.-Ph. Lejeune, N. Schneider & D. Serteyn

  2. Center for Oxygen Research and Development, University of Liège, Liège, Belgium

    T. Franck, N. Schneider, G. Deby-Dupont & D. Serteyn

  3. Department of Genetics, University of Liège, Liège, Belgium

    C. Michaux

  4. Department of Clinical Sciences, Large Animal Surgery, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

    M. Gangl & D. Serteyn

Authors
  1. J.-Ph. Lejeune
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  2. T. Franck
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  3. M. Gangl
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  4. N. Schneider
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  5. C. Michaux
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  6. G. Deby-Dupont
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  7. D. Serteyn
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Correspondence to J.-Ph. Lejeune.

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Lejeune, JP., Franck, T., Gangl, M. et al. Plasma Concentration of Insulin-like Growth Factor I (IGF-I) in Growing Ardenner Horses Suffering from Juvenile Digital Degenerative Osteoarthropathy. Vet Res Commun 31, 185–195 (2007). https://doi.org/10.1007/s11259-006-3385-2

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