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Acute and Chronic Effects of Three Pharmaceutical Drugs on the Tropical Freshwater Cladoceran Ceriodaphnia silvestrii

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Abstract

Among emerging contaminants, pharmaceuticals are one of the most relevant groups of substances found in aquatic environment, due to their universal use, specific physical-chemical properties, and mode of action in aquatic organisms at low concentrations. Considering the magnitude of concentrations and the considerable small amount of information about their potential ecotoxicological effects on wildlife (especially towards organisms from tropical areas), the present study intended to assess the acute and chronic effects of three pharmaceuticals (the analgesic acetaminophen, the anti-inflammatory diclofenac, and the antihypertensive propranolol) in the tropical crustacean species Ceriodaphnia silvestrii. Results of acute exposures showed a considerable variation in toxicity among pharmaceuticals: acetaminophen (EC50 = 40.3 mg L−1) < diclofenac (EC50 = 37.9 mg L−1) < propranolol (EC50 = 3.17 mg L−1), C. silvestrii being more sensitive to the drug propranolol. Data of chronic toxicity tests showed the occurrence of reproductive adverse effects, but also stimulatory phenomena. Propranolol caused a significant increase in fecundity for the concentrations up to 0.0313 mg L−1, and the rate of population increase was significantly augmented from the lower concentration tested. Considering these results and the wide distribution of C. silvestrii in tropical regions, we suggest the use of this species to be used as test organism in ecotoxicity assays performed in such areas, especially for biomonitoring and/or the determination of effects of pharmaceutical drugs.

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Acknowledgments

We are grateful to the Brazilian Research Council (CNPq) for the financial support provided for this research project (No. 142131/2010-5). Bruno Nunes was hired under the program Investigador FCT, co-funded by the Human Potential Operational Program (National Strategic Reference Framework 2007–2013) and European Social Fund (EU). Sara Antunes was funded by a post-doctoral fellowship (SFRH/BPD/109951/2015) by Fundação para a Ciência e Tecnologia (Government of Portugal).

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Authors and Affiliations

  1. Post Graduate Program in Environmental Engineering Sciences, University of São Paulo, Engineering School of São Carlos, Avenida Trabalhador São-carlense, 400, São Carlos, SP, Brazil

    Laira L. Damasceno de Oliveira & Raphael Campitelli-Ramos

  2. Universidade de São Paulo, Escola de Engenharia de São Carlos, Avenida Trabalhador São-carlense, 400, São Carlos, SP, Brazil

    Laira L. Damasceno de Oliveira

  3. Department of Biology, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal

    Bruno Nunes

  4. CESAM, Centre for Environmental and Marine Studies, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal

    Bruno Nunes

  5. Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal

    Sara Cristina Antunes

  6. CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, s/n, 4450-208, Matosinhos, Portugal

    Sara Cristina Antunes

  7. Department of Ecology and Evolutionary Biology, Federal University of São Carlos, Rodovia Washington Luís, km 235, São Carlos, SP, Brazil

    Odete Rocha

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  1. Laira L. Damasceno de Oliveira
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Correspondence to Laira L. Damasceno de Oliveira.

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Damasceno de Oliveira, L.L., Nunes, B., Antunes, S.C. et al. Acute and Chronic Effects of Three Pharmaceutical Drugs on the Tropical Freshwater Cladoceran Ceriodaphnia silvestrii. Water Air Soil Pollut 229, 116 (2018). https://doi.org/10.1007/s11270-018-3765-6

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