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Cross-reactivities of 41 new amphetamine designer drugs to EMIT® immunoassays

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Abstract

Amphetamine designer drugs are central nervous system stimulants, and are widely diffused in illegal markets. Monitoring of drugs of abuse in biological fluids is successfully used for clinical and forensic applications. In particular, the urine matrix allows the verification of drug intake in the short and medium term. In a forensic toxicology laboratory, typical analysis for these drugs involves an immunoassay screening method. Here we describe the cross-reactivity profiles of 41 new amphetamine designer drugs to the urine drug tests EMIT® II Plus (Amphetamines assay and Ecstasy assay).

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Fig. 1

Notes

  1. Accordo, ai sensi dell'articolo 8, comma 2 dell'Intesa in materia di accertamento di assenza di tossicodipendenza, perfezionata nella seduta della Conferenza Unificata del 30 ottobre 2007 (Rep. Atti n. 99/CU), sul documento recante «Procedure per gli accertamenti sanitari di assenza di tossicodipendenza o di assunzione di sostanze stupefacenti o psicotrope in lavoratori addetti a mansioni che comportano particolari rischi per la sicurezza, l’incolumità e la salute di terzi». (Rep. Atti n. 178/CSR). (G.U. Serie Generale n. 236 del 8 ottobre 2008).

References

  1. The American Heritage® Medical Dictionary (2004) Houghton Mifflin Company

  2. United Nations Office on Drugs and Crime (2010) World Drug Report 2010. United Nations Publication, New York

    Google Scholar 

  3. Ensslin HK, Kovar KA, Maurer HH (1996) Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, “Eve”) and its metabolites in urine by GC–MS and fluorescence polarization immunoassay. J Chromatogr B 683:189–197

    Article  CAS  Google Scholar 

  4. Ortuño J, Pizarro N, Farrè M, Mas M, Segura J, Camì J, Brenneisen R, Torre R (1999) Quantification of 3,4-methylenedioxymethamphetamine and its metabolites in plasma and urine by gas chromatography with nitrogen-phosphorus detection. J Chromatogr B 723:221–232

    Article  Google Scholar 

  5. Nieddu M, Boatto G, Sini L, Dessì G (2007) Determination of paramethoxyamphetamine by CE-DAD from urine and plasma samples. J Liq Chromatogr Relat Technol 30:431–438

    Article  CAS  Google Scholar 

  6. Boatto G, Nieddu M, Pirisi MA, Dessì G (2007) Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry. Rapid Commun Mass Spectrom 21:3716–3720

    Article  PubMed  CAS  Google Scholar 

  7. Boatto G, Nieddu M, Dessì G, Manconi P, Cerri R (2007) Determination of four thiophenethylamine designer drugs (2C-T-series) in human plasma by CE-MS. J Chromatogr A 1159:198–202

    Article  PubMed  CAS  Google Scholar 

  8. Nieddu M, Boatto G, Pirisi MA, Dessì G (2010) Determination of four thiophenethylamine designer drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in human urine by CE-MS. Rapid Commun Mass Spectrom 24:2357–2362

    Article  PubMed  CAS  Google Scholar 

  9. Nieddu M, Boatto G, Dessì G (2007) Determination of 4-alkyl 2,5-dimethoxyamphetamine derivatives by CE-MS from urine samples. J Chromatogr B 852:578–581

    Article  CAS  Google Scholar 

  10. Nieddu M, Boatto G, Pirisi MA, Baralla E (2009) Multi-residue analysis of eight thioamphetamine designer drugs in human urine by LC–MS/MS. Rapid Commun Mass Spectrom 23:3051–3056

    Article  PubMed  CAS  Google Scholar 

  11. Boatto G, Nieddu M, Carta A, Pau A, Palomba M, Asproni B, Cerri R (2005) Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection. J Chromatogr B 814:93–98

    Article  CAS  Google Scholar 

  12. Nieddu M, Boatto G, Carta A, Sanna A, Pisano M (2005) Simultaneous determination of ten amphetamine designer drugs in human whole blood by capillary electrophoresis with diode array detector. Biomed Chromatogr 19:737–742

    Article  PubMed  CAS  Google Scholar 

  13. Nieddu M, Boatto G, Pirisi MA, Azara E, Marchetti M (2008) LC–MS analysis of trimethoxyamphetamine designer drugs (TMA series) from urine samples. J Chromatogr B 867:126–130

    Article  CAS  Google Scholar 

  14. Shulgin A (1991) Pihkal, a chemical love story. Transform Press, Berkeley

    Google Scholar 

  15. Nakanishi K, Miki A, Zaitsu K, Kamata H, Shima N, Kamata T, Katagi M, Tatsuno M, Tsuchihashi H, Suzuki K (2012) Cross-reactivities of various phenethylamine-type designer drugs to immunoassays for amphetamines, with special attention to the evaluation of the one-step urine drug test Instant-View™, and the Emit® assays for use in drug enforcement. Forensic Sci Int 217:174–181

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dipartimento di Chimica e Farmacia, Università di Sassari, Via Muroni 23/a, 07100, Sassari, Italy

    Maria Nieddu, Lucia Burrai, Maria Antonietta Pirisi & Gianpiero Boatto

  2. Dipartimento di Scienze Biomediche, Università di Sassari, Via Matteotti 16, 07100, Sassari, Italy

    Claudia Trignano

Authors
  1. Maria Nieddu
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  2. Claudia Trignano
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  3. Lucia Burrai
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  4. Maria Antonietta Pirisi
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  5. Gianpiero Boatto
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Corresponding author

Correspondence to Gianpiero Boatto.

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Nieddu, M., Trignano, C., Burrai, L. et al. Cross-reactivities of 41 new amphetamine designer drugs to EMIT® immunoassays. Forensic Toxicol 31, 133–137 (2013). https://doi.org/10.1007/s11419-012-0156-3

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  • DOI: https://doi.org/10.1007/s11419-012-0156-3

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