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Oxidative stress, nutritional antioxidants and beyond

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Abstract

Free radical-induced oxidative stress contributes to the development of metabolic syndromes (Mets), including overweight, hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain; under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status. Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and anti-inflammatory effect of polyphenols as potential nutritional therapy.

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Acknowledgements

This work was supported by the National Key Research and Development Program (2016YFD0501204, 2018YFD0500405), the Youth Innovation Promotion Association CAS (2016326), the Science and Technology Projects of Hunan Province (2016SK3022, 2017RS3058), Key Project of Research and Development Plan of Hunan Province (2016NK2170), Science and Technology Projects of Changsha City (kq1801059), Youth Innovation Team Project of ISA, CAS (2017QNCXTD_ZCS), the Key Research Program of the Chinese Academy of Sciences (KFZD-SW-219), and the Earmarked Fund for China Agriculture Research System (CARS-35).

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  1. Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China

    Qiuping Guo, Fengna Li, Yehui Duan, Lingyu Zhang, Ruilin Huang & Yulong Yin

  2. Key Laboratory of Agro-ecological Processes in Subtropical Region, Changsha, 410125, China

    Qiuping Guo, Fengna Li, Lingyu Zhang, Ruilin Huang & Yulong Yin

  3. Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, 410125, China

    Qiuping Guo, Fengna Li, Lingyu Zhang, Ruilin Huang & Yulong Yin

  4. Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, 410125, China

    Qiuping Guo, Fengna Li, Lingyu Zhang, Ruilin Huang & Yulong Yin

  5. University of Chinese Academy of Sciences, Beijing, 100039, China

    Qiuping Guo & Lingyu Zhang

  6. Hunan Co-Innovation Center of Animal Production Safety, Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, Changsha, 410128, China

    Fengna Li

  7. Laboratory of Animal Nutrition and Human Health, School of Biology, Hunan Normal University, Changsha, 410018, China

    Chaoyue Wen, Wenlong Wang & Yulong Yin

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  1. Qiuping Guo
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Guo, Q., Li, F., Duan, Y. et al. Oxidative stress, nutritional antioxidants and beyond. Sci. China Life Sci. 63, 866–874 (2020). https://doi.org/10.1007/s11427-019-9591-5

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