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Sound transmission in porcine thorax through airway insonification

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Abstract

Many pulmonary injuries and pathologies may lead to structural and functional changes in the lungs resulting in measurable sound transmission changes on the chest surface. Additionally, noninvasive imaging of externally driven mechanical wave motion in the chest (e.g., using magnetic resonance elastography) can provide information about lung structural property changes and, hence, may be of diagnostic value. In the present study, a comprehensive computational simulation (in silico) model was developed to simulate sound wave propagation in the airways, lung, and chest wall under normal and pneumothorax conditions. Experiments were carried out to validate the model. Here, sound waves with frequency content from 50 to 700 Hz were introduced into airways of five porcine subjects via an endotracheal tube, and transmitted waves were measured by scanning laser Doppler vibrometry at the chest wall surface. The computational model predictions of decreased sound transmission with pneumothorax were consistent with experimental measurements. The in silico model can also be used to visualize wave propagation inside and on the chest wall surface for other pulmonary pathologies, which may help in developing and interpreting diagnostic procedures that utilize sound and vibration.

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Acknowledgments

Financial support of the National Institutes of Health (Grant No. EB012142) is acknowledged.

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Authors and Affiliations

  1. Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, 842 W. Taylor St, 2039 ERF, Chicago, IL, 60607, USA

    Ying Peng, Zoujun Dai, Brian M. Henry & Thomas J. Royston

  2. University of Central Florida, Orlando, FL, 32816, USA

    Hansen A. Mansy & Richard H. Sandler

  3. Nemours Children’s Hospital, Orlando, FL, 32827, USA

    Hansen A. Mansy & Richard H. Sandler

  4. Rush University Medical Center, Chicago, IL, 60612, USA

    Robert A. Balk

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  1. Ying Peng
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  2. Zoujun Dai
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Correspondence to Ying Peng.

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Peng, Y., Dai, Z., Mansy, H.A. et al. Sound transmission in porcine thorax through airway insonification. Med Biol Eng Comput 54, 675–689 (2016). https://doi.org/10.1007/s11517-015-1358-8

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  • DOI: https://doi.org/10.1007/s11517-015-1358-8

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