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Anorexia nervosa und Bulimia nervosa

Anorexia nervosa and bulimia nervosa

  • Leitthema
  • Published:
Der Nephrologe Aims and scope

Zusammenfassung

Neben den allgemein bekannten Störungen des Säure-Basen-Haushalts durch renale Erkrankungen gibt es auch extrarenale Krankheitsbilder, die mit typischen metabolischen Störungen einhergehen. Unter diesen sind die Essstörungen Anorexia nervosa (AN) und Bulimia nervosa (BN), das Kurzdarmsyndrom sowie das Vorhandensein einer alternativen Harnableitung nach Zystektomie hervorzuheben. Diese drei Erkrankungen zeichnen sich zudem durch das erhöhte Risiko einer Nierenfunktionseinschränkung und Nephrolithiasis aus. Die metabolische Alkalose ist kennzeichnend für die AN und BN, dagegen wird bei Kurzdarmsyndrom und nach alternativer Harnableitung überwiegend eine metabolische Azidose beobachtet. Regelmäßige Kontrollen der Elektrolyte, des Säure-Basen-Status sowie der Nierenfunktion sind im Kurz- und Langzeitverlauf erforderlich.

Abstract

Besides the commonly known disturbances of the acid-base balance caused by renal diseases, there also exist extrarenal disease symptoms that are associated with typical metabolic disturbances. These include the eating disorders anorexia nervosa (AN) and bulimia nervosa (BN), the short-bowel syndrome and the presence of an alternative urinary diversion after cystectomy. These three diseases are also characterized by an increased risk of renal functional impairment and nephrolithiasis. Metabolic alkalosis is distinctive for AN (purging type) and BN; however, metabolic acidosis is predominantly observed in short bowel syndrome and after urinary diversion. Regular controls of electrolytes, acid-base status and renal function are required in the short and long term.

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Literatur

  1. Agarwal R, Afzalpurkar R, Fordtran JS (1994) Pathophysiology of potassium absorption and secretion by the human intestine. Gastroenterology 107:548–571

    Article  CAS  PubMed  Google Scholar 

  2. Amirlak I, Dawson KP (2000) Bartter syndrome: an overview. QJM 93:207–215

    Article  CAS  PubMed  Google Scholar 

  3. Banerjee A, Warwicker P (2002) Acute renal failure and metabolic disturbances in the short bowel syndrome. QJM 95:37–40

    Article  CAS  PubMed  Google Scholar 

  4. Bouquegneau A, Dubois BE, Krzesinski JM et al (2012) Anorexia nervosa and the kidney. Am J Kidney Dis 60:299–307

    Article  PubMed  Google Scholar 

  5. Campbell K, Peebles R (2014) Eating disorders in children and adolescents: state of the art review. Pediatrics 134:582–592

    Article  PubMed  Google Scholar 

  6. Cruz DN, Huot SJ (1997) Metabolic complications of urinary diversions: an overview. Am J Med 102:477–484

    Article  CAS  PubMed  Google Scholar 

  7. Delanaye P, Cavalier E, Radermecker RP et al (2008) Cystatin C or creatinine for detection of stage 3 chronic kidney disease in anorexia nervosa. Nephron Clin Pract 110:c158–163

    Article  CAS  PubMed  Google Scholar 

  8. Golimbu M, Morales P (1975) Jejunal conduits: technique and complications. J Urol 113:787–795

    Article  CAS  PubMed  Google Scholar 

  9. Gosalbez R Jr., Woodard JR, Broecker BH et al (1993) Metabolic complications of the use of stomach for urinary reconstruction. J Urol 150:710–712

    Article  PubMed  Google Scholar 

  10. Harraz AM, Osman Y, El-Halwagy S et al (2015) Risk factors of hospital readmission after radical cystectomy and urinary diversion: analysis of a large contemporary series. BJU Int 115:94–100

    Article  PubMed  Google Scholar 

  11. Hautmann RE, De Petriconi R, Gottfried HW et al (1999) The ileal neobladder: complications and functional results in 363 patients after 11 years of followup. J Urol 161:422–427

    Article  CAS  PubMed  Google Scholar 

  12. Hautmann RE, De Petriconi RC, Volkmer BG (2011) 25 years of experience with 1,000 neobladders: long-term complications. J Urol 185:2207–2212

    Article  PubMed  Google Scholar 

  13. Herzog W, Deter HC, Fiehn W et al (1997) Medical findings and predictors of long-term physical outcome in anorexia nervosa: a prospective, 12-year follow-up study. Psychol Med 27:269–279

    Article  CAS  PubMed  Google Scholar 

  14. Iwasaki Y, Asai M, Yoshida M et al (2007) Impaired parathyroid hormone response to hypocalcemic stimuli in a patient with hypomagnesemic hypocalcemia. J Endocrinol Invest 30:513–516

    Article  CAS  PubMed  Google Scholar 

  15. Ladefoged K, Olgaard K (1985) Sodium homeostasis after small-bowel resection. Scand J Gastroenterol 20:361–369

    Article  CAS  PubMed  Google Scholar 

  16. Mehler PS, Krantz MJ, Sachs KV (2015) Treatments of medical complications of anorexia nervosa and bulimia nervosa. J Eat Disord 3:15

    Article  PubMed  PubMed Central  Google Scholar 

  17. Mehler PS, Linas S (2002) Use of a proton-pump inhibitor for metabolic disturbances associated with anorexia nervosa. N Engl J Med 347:373–374 (author reply 373–374)

    Article  PubMed  Google Scholar 

  18. Mehler PS, Rylander M (2015) Bulimia nervosa – medical complications. J Eat Disord 3:12

    Article  PubMed  PubMed Central  Google Scholar 

  19. Mills RD, Studer UE (1999) Metabolic consequences of continent urinary diversion. J Urol 161:1057–1066

    Article  CAS  PubMed  Google Scholar 

  20. Nightingale JM (2003) The medical management of intestinal failure: methods to reduce the severity. Proc Nutr Soc 62:703–710

    Article  PubMed  Google Scholar 

  21. Reungjui S, Roncal CA, Sato W et al (2008) Hypokalemic nephropathy is associated with impaired angiogenesis. J Am Soc Nephrol 19:125–134

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Stampfer DS, Mcdougal WS (1997) Inhibition of the sodium/hydrogen antiport by ammonium ion. J Urol 157:362–365

    Article  CAS  PubMed  Google Scholar 

  23. Stein R, Hohenfellner M, Pahernik S et al (2012) Urinary diversion—approaches and consequences. Dtsch Arztebl Int 109:617–622

    PubMed  PubMed Central  Google Scholar 

  24. Stein R, Rubenwolf P (2014) Metabolic consequences after urinary diversion. Front Pediatr 2:15

    Article  PubMed  PubMed Central  Google Scholar 

  25. Stein R, Schroder A, Thuroff JW (2012) Bladder augmentation and urinary diversion in patients with neurogenic bladder: non-surgical considerations. J Pediatr Urol 8:145–152

    Article  PubMed  Google Scholar 

  26. Tanrikut C, Mcdougal WS (2004) Acid-base and electrolyte disorders after urinary diversion. World J Urol 22:168–171

    Article  PubMed  Google Scholar 

  27. Tappenden KA (2014) Pathophysiology of short bowel syndrome: considerations of resected and residual anatomy. JPEN J Parenter Enteral Nutr 38:14S–22S

    Article  CAS  PubMed  Google Scholar 

  28. Winston AP (2012) The clinical biochemistry of anorexia nervosa. Ann Clin Biochem 49:132–143

    Article  CAS  PubMed  Google Scholar 

  29. Zabell JR, Adejoro O, Konety BR et al (2015) Risk of end stage kidney disease after radical cystectomy according to urinary diversion type. J Urol 193:1283–1287

    Article  PubMed  Google Scholar 

  30. Zipfel S, Lowe B, Reas DL et al (2000) Long-term prognosis in anorexia nervosa: lessons from a 21–year follow-up study. Lancet 355:721–722

    Article  CAS  PubMed  Google Scholar 

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Correspondence to M. Huber.

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M. Huber gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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U. Heemann, München

R.P. Wüthrich, Zürich

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Huber, M. Anorexia nervosa und Bulimia nervosa. Nephrologe 13, 12–18 (2018). https://doi.org/10.1007/s11560-017-0205-3

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  • DOI: https://doi.org/10.1007/s11560-017-0205-3

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