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IL-17 contributes to autoimmune hepatitis

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Summary

The role of interleukin-17 (IL-17) in autoimmune hepatitis (AIH) was investigated. A mouse model of experimental autoimmune hepatitis was established, and the syngeneic S-100 antigen emulsified in complete Freud’s adjuvant was injected intraperitoneally into adult male C57BL/6 mice. The IL-17 expression in serum and the livers of the mice models was detected by using ELISA and immunohistochemistry, respectively. IL-17 neutralizing antibody was used to study the biological effect of IL-17 in the experimental AIH. IL-17 neutralizing antibody in vivo administration alleviated the hepatic inflammation and ALT level in the AIH model. IL-17 in the peripheral blood mononuclear cells (PBMC) of AIH patients was measured by using real-time PCR method. The results showed that IL-17 level was significantly up-regulated in AIH patients and mice models. It was concluded that IL-17 contributed to the development of AIH and might be a potential therapeutic target of AIH.

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Authors and Affiliations

  1. Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Haijing Yu  (余海静), Jiaquan Huang  (黄加权), Yang Liu  (刘 阳), Guo Ai  (艾 国), Weiming Yan  (严伟明), Xiaojing Wang  (王晓晶) & Qin Ning  (宁 琴)

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  1. Haijing Yu  (余海静)
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  2. Jiaquan Huang  (黄加权)
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  3. Yang Liu  (刘 阳)
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  4. Guo Ai  (艾 国)
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  5. Weiming Yan  (严伟明)
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  6. Xiaojing Wang  (王晓晶)
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  7. Qin Ning  (宁 琴)
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Corresponding author

Correspondence to Qin Ning  (宁 琴).

Additional information

This project was supported by a grant from National “973” Project in viral hepatitis (MOST, No. 2007CB512900).

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Yu, H., Huang, J., Liu, Y. et al. IL-17 contributes to autoimmune hepatitis. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 30, 443–446 (2010). https://doi.org/10.1007/s11596-010-0446-0

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  • DOI: https://doi.org/10.1007/s11596-010-0446-0

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