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Hemorrhage in cerebral fat embolisms in a cat model using triolein dependent on the physical properties of triolein

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Abstract

Purpose

Hemorrhage is a finding of clinical fat embolism syndrome. The purpose of the present study was to evaluate the occurrence of hemorrhage in the cat brain by SW MR imaging after infusion of triolein as a bolus or as an emulsion into the carotid artery.

Materials and methods

Twenty-two cats were divided into two groups according to the type of triolein infused: group 1 (n = 11) was infused with a 0.1 ml triolein bolus, group 2 (n = 11) with triolein emulsion containing 0.1 ml triolein in 20 ml saline. SW imaging was performed before and after triolein infusion (at 2 h, 1 and 4 days). After MR imaging on day 4, cats were sacrificed and brains were immediately excised. Hemorrhage was evaluated using H&E staining.

Results

Hemorrhage was observed in eight cats in group 1, in no cats in group 2. Hemorrhage on SW images was found to correspond with light microscopy.

Conclusions

SW images revealed hemorrhage in lesion hemispheres infused with triolein bolus. However, there was no evidence of hemorrhage infused with emulsified triolein. Thus, the occurrence of hemorrhage in cerebral fat embolism may depend on fat status.

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Acknowledgments

This study was supported by Biomedical Research Institute Grant (2011-2), Pusan National University Hospital.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Radiology, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea

    Yong-Woo Kim

  2. Department of Radiology, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, 10 1-Ga, Ami-Dong, Seo-Ku, Pusan, 602-739, Republic of Korea

    Hak J. Kim

  3. Pusan National University School of Medicine, Pusan National University Postgraduate School, Pusan, Republic of Korea

    Seon H. Choi & Lee Hwangbo

  4. Department of Preventive Medicine, Pusan National University School of Medicine, Pusan, Republic of Korea

    Byungmann Cho

  5. Department of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea

    Dong C. Kim

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  1. Yong-Woo Kim
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  2. Hak J. Kim
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  3. Seon H. Choi
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Corresponding author

Correspondence to Hak J. Kim.

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Cite this article

Kim, YW., Kim, H.J., Choi, S.H. et al. Hemorrhage in cerebral fat embolisms in a cat model using triolein dependent on the physical properties of triolein. Jpn J Radiol 32, 30–37 (2014). https://doi.org/10.1007/s11604-013-0265-x

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  • DOI: https://doi.org/10.1007/s11604-013-0265-x

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