Abstract
Polycomb group (PcG) proteins, which are conserved from invertebrates to mammals, are associated with epigenetic regulation of many cell fates. The activities of PcG proteins are largely associated with modulation of specific immune reactions. However, no study has attempted to explore the role of Phc2, a subunit of polycomb repressive complex 1, on helper T (Th) cell activation. Presently, Phc2 expression was down-regulated in activated Th cells. The ectopic expression of Phc2 in Th cells inhibited Th cell proliferation and secretion of interleukin-2 from Th cells upon antigen-specific activation. Phc2 may act as a negative regulator that inhibits the activity of Th cells.
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Acknowledgments
This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010-0023283). This work was also supported by Next-Generation BioGreen 21 program (No. PJ008089), Rural Development Administration, Republic of Korea.
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Cho, KW., Bae, J., Lee, S.J. et al. Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation. In Vitro Cell.Dev.Biol.-Animal 49, 360–370 (2013). https://doi.org/10.1007/s11626-013-9618-0
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DOI: https://doi.org/10.1007/s11626-013-9618-0