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Environmental chemical carcinogens induce transformation of breast epithelial cells from women with familial history of breast cancer

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References

  1. Bartkova, J.; Lukas, J.; Müller, H., et al. Cyclin D1 protein expression and function in human breast cancer. Int. J. Cancer 57:353–361; 1994.

    Article  PubMed  CAS  Google Scholar 

  2. Bronner, M. P.; Culin, C.; Reed, J. C., et al. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am. J. Pathol. 146:20–26; 1995.

    PubMed  CAS  Google Scholar 

  3. Buckley, M. F.; Sweeney, K. J. E.; Hamilton, J. A., et al. Expression and amplification of cyclin genes in human breast cancer. Oncogene 8:2127–2133; 1993.

    PubMed  CAS  Google Scholar 

  4. Calaf, G.; Russo, J. Transformation of human breast epithelial cells by chemical carcinogens. Carcinogenesis 14:483–492; 1993.

    Article  PubMed  CAS  Google Scholar 

  5. Chan, W. K.; Poulsom, R.; Lu, Q. L., et al. Bcl-2 expression in invasive mammary carcinoma: correlation with apoptosis, hormone receptors and p53 expression. J. Pathol. 169:153A; 1993.

    Google Scholar 

  6. Chang, S. E. In vitro transformation of human epithelial cells. Biochim. Biophys. Acta 823:161–194; 1986.

    PubMed  CAS  Google Scholar 

  7. DiPaolo, J. A. Relative difficulties in transforming human and animal cells in vitro. J. Natl. Cancer Inst. 70:3–8; 1983.

    PubMed  CAS  Google Scholar 

  8. Doll, R. An epidemiological perspective of the biology of cancer. Cancer Res. 38:3573–3583; 1978.

    PubMed  CAS  Google Scholar 

  9. Farber, E. The multistep nature of cancer development. Cancer Res. 44:4217–4223; 1984.

    PubMed  CAS  Google Scholar 

  10. Gee, J. M.; Robertson, J. F.; Ellis, I. O., et al. Immunocytochemical localization of BCL-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. Int. J. Cancer 59:619–628; 1994.

    Article  PubMed  CAS  Google Scholar 

  11. Gillet, C.; Fantl, V.; Smith, R., et al. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res. 54:1812–1817; 1994.

    Google Scholar 

  12. Han, E. K. H.; Sgambato, A.; Jiang, W., et al. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the Sphase and inhibits growth. Oncogene 10:953–961; 1995.

    PubMed  CAS  Google Scholar 

  13. Hinds, P. W.; Dowdy, S. F.; Eaton, E. N., et al. Function of a human cyclin gene as an oncogene. Proc. Natl. Acad. Sci. USA 91:709–713; 1994.

    Article  PubMed  CAS  Google Scholar 

  14. Hockenbery, D.; Nunez, G.; Milliman, C., et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 349:334–336; 1990.

    Article  Google Scholar 

  15. Lauwers, G. Y.; Scott, G. V.; Hendricks, J. Immunohistochemical evidence of aberrant bcl-2 protein expression in gastric epithelial dysplasia. Cancer 73:2900–2904; 1994.

    Article  PubMed  CAS  Google Scholar 

  16. Lu, P.J.; Lu, Q. L.; Rughetti, A., et al. Bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cells. J. Cell Biol. 129:1363–1378; 1995.

    Article  PubMed  CAS  Google Scholar 

  17. Lynch, H. T.; Lynch, J. F. Breast cancer genetics in an oncology clinic: 328 consecutive patients. Cancer Genet. Cytogenet. 22:369–371; 1986.

    Article  PubMed  CAS  Google Scholar 

  18. Marcus, J. N.; Watson, P.; Page, D. L., et al. Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage. Cancer 77:697–709; 1996.

    Article  PubMed  CAS  Google Scholar 

  19. Marshall, E. Search for a killer: focus shifts from fat to hormones. Science 259:618–621; 1993.

    Article  PubMed  CAS  Google Scholar 

  20. McDonnell, T. J.; Deane, N.; Platt, F. M., et al. Bcl-2 immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79–88; 1989.

    Article  PubMed  CAS  Google Scholar 

  21. McDonnell, T.J.; Korsmeyer, S. J. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the 4(14:18). Nature 349:254–256; 1991.

    Article  PubMed  CAS  Google Scholar 

  22. Montesano, R.; Tomatis, L. Legislation concerning chemical carcinogens in several industrialized countries. Cancer Res. 37:310–316; 1977.

    PubMed  CAS  Google Scholar 

  23. Motokura, T.; Bloom, T.; Kim, H. G., et al. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350:512–515; 1991.

    Article  PubMed  CAS  Google Scholar 

  24. Musgrove, E. A.; Lee, C. S.; Buckley, M. F., et al. Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc. Natl. Acad. Sci. USA 91:8022–8026; 1994.

    Article  PubMed  CAS  Google Scholar 

  25. Nakagawa, K.; Yamamura, K.; Maeda, S., et al. Bcl-2 expression in epidermal keratinocytic diseases. Cancer 74:1720–1724; 1994.

    Article  PubMed  CAS  Google Scholar 

  26. Nataraj, A.; Pathak, S.; Hopwood, V. L., et al. Bcl-2 oncogene blocks differentiation and extends viability but does not immortalize normal human keratinocytes. Int. J. Oncol. 4:1211–1218; 1994.

    Google Scholar 

  27. Putnam, D. L.; Park, D. K.; Rhim, J. S., et al. Correlation of cellular aggregation of transformed cells and their growth in soft agar and tumorigenic potential. Proc. Soc. Exp. Biol. Med. 155:487–494; 1977.

    Google Scholar 

  28. Reed, J. C.; Cuddy, M.; Haldar, S., et al. BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense. Proc. Natl. Acad. Sci. USA 87:3660–3664; 1990.

    Article  PubMed  CAS  Google Scholar 

  29. Russo, J.; Barnabas, N.; Zhang, P. L., et al. Molecular basis of breast cell transformation. Radiat. Oncol. Invest. 3:424–429; 1996.

    Article  Google Scholar 

  30. Russo, J.; Calaf, G.; Sohi, N., et al. Critical steps in breast carcinogenesis. Ann. NY Acad. Sci. 698:1–20; 1993.

    Article  PubMed  CAS  Google Scholar 

  31. Russo, J.; Reina, D.; Frederick, J., et al. Expression of phenotypical changes by human breast epithelial cells treated with carcinogens in vitro. Cancer Res. 48:2837–2857; 1988.

    PubMed  CAS  Google Scholar 

  32. Sabourin, J. C.; Martin, A.; Baruch, J., et al. Bcl-2 expression in normal breast tissue during the menstrual cycle. Int. J. Cancer 59:1–6; 1994.

    Article  PubMed  CAS  Google Scholar 

  33. Seidman, H.; Stellman, S. D.; Mushinski, M. H. A different perspective on breast cancer risk factors: some implications of the nonattributable risk. Ca Cancer J. Clin. 32:301–313; 1982.

    PubMed  CAS  Google Scholar 

  34. Sherr, C. J. G1 phase progression: cycling on cue. Cell 79:551–555; 1994.

    Article  PubMed  CAS  Google Scholar 

  35. Stampfer, M. R.; Bartley, J. C. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. Proc. Natl. Acad. Sci. USA 82:2394–2398; 1984.

    Article  Google Scholar 

  36. Stoll, B. A. Reducing breast cancer risk in women. Dordrecht, Netherlands: Kluwer Academic Publishers; 1995:3–9.

    Google Scholar 

  37. Traul, K. A.; Takayama, K.; Kachevsky, V., et al. A rapid in vitro assay for carcinogenicity of chemical substances in mammalian cells utilizing an attachment independence endpoint-2-assay validations. J. Appl. Toxicol. 1:190; 1981.

    Article  PubMed  CAS  Google Scholar 

  38. Tsujimoto, Y.; Croce, C. M. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Natl. Acad. Sci. USA 83:5214–5218; 1986.

    Article  PubMed  CAS  Google Scholar 

  39. Weistat-Saslow, D.; Merino, M. J.; Richard, E. M., et al. Overexpression of cyclin D mRNA distinguish invasive and in situ breast carcinomas from non-malignant lesions. Nature Med. 1:1257–1260; 1995.

    Article  Google Scholar 

  40. Zhang, S. Y.; Camano, J.; Cooper, F., et al. Immunohistochemistry of cyclin D1 in human breast cancer. Am. J. Clin. Pathol. 102:695–698; 1994.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Breast Cancer Research Laboratory, Fox Chase Cancer Center, 7701 Burholme Avenue, 19111, Philadelphia, Pennsylvania

    Y. F. Hu, I. H. Russo & U. Zalipsky

  2. Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 68178, Omaha, Nebraska

    H. T. Lynch

Authors
  1. Y. F. Hu
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  2. H. T. Lynch
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  3. I. H. Russo
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  4. J. Russo
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  5. U. Zalipsky
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Hu, Y.F., Lynch, H.T., Russo, I.H. et al. Environmental chemical carcinogens induce transformation of breast epithelial cells from women with familial history of breast cancer. In Vitro Cell.Dev.Biol.-Animal 33, 495–498 (1997). https://doi.org/10.1007/s11626-997-0090-6

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  • DOI: https://doi.org/10.1007/s11626-997-0090-6

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