Abstract
Objective: To investigate the expression of angiogenic factors, basic fibroblast, growth factor (bFGF) and transforming growth factor (TGF)-β1 in osteosarcoma, its association with neovascularization and prognosis. Methods: The expression of bFGF, β1 and their receptors, as well as intratumoral microvessel count (MVD) were studied in 80 osteosarcomas by immunohistochemical staining and morphometry. The relationship between the angiogenic factors expression and prognosis was evaluated by a multivariate analysis using Cox proportion hazard model. Results: Among 80 cases of osteosarcoma, 46 cases were positive for TGF/TGF-β (57.5%), and 31 cases for β1, (RI)(38.8%) respectively. The MVD and bFGF, TGFβ1 1 were important indicators to predict the prognosis of patients with osteosarcoma by the Cox proportion hazard model analysis. Conclusion: The angiogenic factors bFGF and TGF-β1 are involved in the angiogenesis of osteosarcoma, and the angiogenesis influences the prognosis. Also they may be useful in the evaluation of the prognosis of patients with osteosarcoma.
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This work was supported by a grant from the Youth Scientific Research Foundation of the 9th Five-year Plan of the PLA.
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Dong, W., Hualiang, X., Zengpeng, L. et al. Expression of basic fibroblast growth factor, transforming growth factor β1 and their 3 receptors in osteosarcoma and its relationship to angiogenesis. Chin. J. Cancer Res. 11, 275–278 (1999). https://doi.org/10.1007/s11670-999-0033-8
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DOI: https://doi.org/10.1007/s11670-999-0033-8