Skip to main content

Advertisement

Log in

Behavior of Type 2 Diabetes Mellitus in Morbid Obese Patients Submitted to Gastric Bypass

  • Research Article
  • Published:
Obesity Surgery Aims and scope Submit manuscript

Abstract

Introduction

Surgical treatment of obesity has not only resulted in weight loss, but also the control of associated diseases in the postoperative period. The aim of this study was to determine the post-op response of type 2 diabetes mellitus (DM2) to gastric bypass.

Methods

A historical cohort study was performed involving all the diabetic, morbid obese patients who underwent gastric bypass during the period of May 2000 to October 2006 at the Centro da Obesidade Mórbida. Patient records were reviewed with regard to sex, age, anthropometric measurements, glycemia, glycosylated hemoglobin, pre-op insulin, and DM2 outcome.

Results

A total of 125 diabetic, morbid obese patients were operated; they had a mean age of 42.6 ± 9.7 years and body mass index of 49 ± 8.3 kg/m2. Of these patients, 63 (50.4%) required medication for control of DM2, and the rest managed only with diet.

Of these 63 patients, 43 (68.2%) achieved control of DM2 and were discharged without the need for antidiabetic medication, and 20 (31.7%) were discharged still on medication. One month after surgery, seven more patients discontinued medication for DM2, and 18 months after surgery, 97.6% of the patients showed control of DM2.

Conclusion

Gastric bypass is effective in controlling DM2 in morbid obese patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. MacDonald KG Jr, Long SD, Swanson MS, et al. The gastric bypass operation reduces the progression and mortality of non-insulin-dependent diabetes mellitus. J Gastrointest Surg 1997;1:213–20; discussion 20.

    Article  PubMed  Google Scholar 

  2. Sjostrom CD. Surgery as an intervention for obesity. Results from the Swedish obese subjects study. Growth Horm IGF Res 2003;13(Suppl A):S22–6.

    Article  PubMed  Google Scholar 

  3. Cummings DE, Overduin J, Foster-Schubert KE. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 2004;89:2608–15.

    Article  PubMed  CAS  Google Scholar 

  4. Gumbs AA, Modlin IM, Ballantyne GH. Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss. Obes Surg 2005;15:462–73.

    Article  PubMed  Google Scholar 

  5. Lima J, Helena L, Oliveira S, et al. Rapid resolution of diabetes after gastric bypass. Obes Surg 2005;15:448–9.

    Article  PubMed  Google Scholar 

  6. Mason EE. Ileal [correction of ilial] transposition and enteroglucagon/GLP-1 in obesity (and diabetic?) surgery. Obes Surg 1999;9:223–8.

    Article  PubMed  CAS  Google Scholar 

  7. Mason EE. The mechanisms of surgical treatment of type 2 diabetes. Obes Surg 2005;15:459–61.

    Article  PubMed  Google Scholar 

  8. Patriti A, Facchiano E, Sanna A, et al. The enteroinsular axis and the recovery from type 2 diabetes after bariatric surgery. Obes Surg 2004;14:840–8.

    Article  PubMed  Google Scholar 

  9. Pinkney JH, Sjostrom CD, Gale EA. Should surgeons treat diabetes in severely obese people? Lancet 2001;357:1357–9.

    Article  PubMed  CAS  Google Scholar 

  10. Pories WJ. Why does the gastric bypass control type 2 diabetes mellitus? Obes Surg 1992;2:303–13.

    Article  PubMed  Google Scholar 

  11. Pories WJ, Albrecht RJ. Etiology of type II diabetes mellitus: role of the foregut. World J Surg 2001;25:527–31.

    Article  PubMed  CAS  Google Scholar 

  12. Pories WJ, Swanson MS, MacDonald KG, et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg 1995;222:339–50; discussion 50–2.

    Article  PubMed  CAS  Google Scholar 

  13. Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg 2006;244:741–9.

    Article  PubMed  Google Scholar 

  14. Rubino F, Gagner M. Potential of surgery for curing type 2 diabetes mellitus. Ann Surg 2002;236:554–9.

    Article  PubMed  Google Scholar 

  15. Rubino F, Gagner M, Gentileschi P, et al. The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg 2004;240:236–42.

    Article  PubMed  Google Scholar 

  16. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004;292:1724–37.

    Article  PubMed  CAS  Google Scholar 

  17. Ballantyne GH. Peptide YY(1–36) and peptide YY(3–36): Part II. Changes after gastrointestinal surgery and bariatric surgery. Obes Surg 2006;16:795–803.

    Article  PubMed  Google Scholar 

  18. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486–97.

    Article  Google Scholar 

  19. Narayan KM, Gregg EW, Fagot-Campagna A, et al. Diabetes—a common, growing, serious, costly, and potentially preventable public health problem. Diabetes Res Clin Pract 2000;50(Suppl 2):S77–84.

    Article  PubMed  Google Scholar 

  20. Rubino F, Marescaux J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg 2004;239:1–11.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cláudio Corá Mottin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mottin, C.C., Vontobel Padoin, A., Schroer, C.E. et al. Behavior of Type 2 Diabetes Mellitus in Morbid Obese Patients Submitted to Gastric Bypass. OBES SURG 18, 179–181 (2008). https://doi.org/10.1007/s11695-007-9249-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11695-007-9249-1

Keywords

Navigation