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A Prospective Study of the Conservative Management of Asymptomatic Preoperative and Postoperative Gallbladder Disease in Bariatric Surgery

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Abstract

Introduction

Bariatric surgery is the most effective therapy for weight loss in patients with morbid obesity. One of the most common long-term complications includes cholelithiasis. There is not a clear consensus in how to treat an asymptomatic gallbladder disease before and after bariatric surgery.

Methods

Prospective study with every patient submitted to bariatric surgery from 2012 to 2014. The gallbladder status was assessed with an ultrasound before and after surgery (12 months), and a conservative management was conducted for patients with asymptomatic disease (preoperative and de novo); the need for delayed cholecystectomy was reported. Secondarily, an analysis of weight loss (%EWL) and gallbladder status was performed.

Results

Two-hundred and two bariatric surgeries were performed. The global incidence of preoperative gallbladder disease was 34.3 %, with 14.2 % presenting sludge, 20.1 % asymptomatic gallstones, and 2.3 % symptomatic gallstones. The final analysis was based on 146 patients; female sex comprised 81.1 % of cases with a mean age of 38.5 years. After 12 months, de novo gallbladder disease was observed in 21.2 %. The overall rate of cholecystectomy because of symptomatic disease after 12 months was 3.4 % (2 % developed acute cholecystitis). There were no differences in %EWL between patients with de novo gallbladder disease and those without.

Conclusion

Conservative management of asymptomatic gallbladder disease in candidates to bariatric surgery is safe and can be offered in every case, based on the low percentage of patients requiring further cholecystectomy after 12 months. Also, a conservative management can be offered to patients developing de novo sludge/cholelithiasis without related symptoms.

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References

  1. Angrisani L, Santonicola A, Iovino P, et al. Bariatric surgery worldwide 2013. Obes Surg. 2015;25:1822–32.

    Article  CAS  PubMed  Google Scholar 

  2. Bozkurt S. Complications in bariatric surgery. Eur J Endosc Laparosc Surg. 2014;1:238–46.

    Google Scholar 

  3. Fobi M, Lee H, Igwe D, et al. Prophylactic cholecystectomy with gastric bypass operation: incidence of gallbladder disease. Obes Surg. 2002;12:350–3.

    Article  PubMed  Google Scholar 

  4. Jonas E, Marsk R, Rasmussen F, Freedman J. Incidence of postoperative gallstone disease after antiobesity surgery: population-based study from Sweden. Surg Obes Relat Dis. 2010;6:54–8.

    Article  PubMed  Google Scholar 

  5. Dittrick GW, Thompson JS, Campos D, et al. Gallbladder pathology in morbid obesity. Obes Surg. 2005;15:238–42.

    Article  PubMed  Google Scholar 

  6. Worni M, Guller U, Shah A, et al. Cholecystectomy concomitant with laparoscopic gastric bypass: a trend analysis of the nationwide inpatient sample from 2001 to 2008. Obes Surg. 2012;22:220–9.

    Article  PubMed  Google Scholar 

  7. Shiffman ML, Sugerman HJ, Kellum JM, Moore EW. Changes in gallbladder bile composition following gallstone formation and weight reduction. Gastroenterology. 1992;103:214–21.

    Article  CAS  PubMed  Google Scholar 

  8. Liddle RA, Goldstein RB, Saxton J. Gallstone formation during weight-reduction dieting. Arch Intern Med. 1989;149:1750–3.

    Article  CAS  PubMed  Google Scholar 

  9. de Oliveira C IB, Adami Chaim E, da Silva BB. Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg. 2003;13:625–8.

    Article  Google Scholar 

  10. Villegas L, Schneider B, Provost D, et al. Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg. 2004;14:206–11.

    Article  PubMed  Google Scholar 

  11. Mason EE, Renquist KE. Gallbladder management in obesity surgery. Obes Surg. 2002;12:222–9.

    Article  PubMed  Google Scholar 

  12. Quesada BM, Kohan G, Roff HE, et al. Management of gallstones and gallbladder disease in patients undergoing gastric bypass. World J Gastroenterol. 2010;16:2075–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Amstutz S, Michel JM, Kopp S, Egger B. Potential benefits of prophylactic cholecystectomy in patients undergoing bariatric bypass surgery. Obes Surg. 2015;25:2054–60.

    Article  PubMed  Google Scholar 

  14. Tarantino I, Warschkow R, Steffen T, et al. Is routine cholecystectomy justified in severely obese patients undergoing a laparoscopic Roux-en-Y gastric bypass procedure? A comparative cohort study. Obes Surg. 2011;21:1870–8.

    Article  PubMed  Google Scholar 

  15. Tucker ON, Fajnwaks P, Szomstein S, Rosenthal RJ. Is concomitant cholecystectomy necessary in obese patients undergoing laparoscopic gastric bypass surgery? Surg Endosc. 2008;22:2450–4.

    Article  CAS  PubMed  Google Scholar 

  16. Weiss AC, Inui T, Parina R, et al. Concomitant cholecystectomy should be routinely performed with laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2015;29:3106–11.

    Article  PubMed  Google Scholar 

  17. Liem RK, Niloff PH. Prophylactic cholecystectomy with open gastric bypass operation. Obes Surg. 2004;14:763–5.

    Article  PubMed  Google Scholar 

  18. Nougou A, Suter M. Almost routine prophylactic cholecystectomy during laparoscopic gastric bypass is safe. Obes Surg. 2008;18:535–9.

    Article  CAS  PubMed  Google Scholar 

  19. D'Hondt M, Sergeant G, Deylgat B, et al. Prophylactic cholecystectomy, a mandatory step in morbidly obese patients undergoing laparoscopic Roux-en-Y gastric bypass? J Gastrointest Surg. 2011;15:1532–6.

    Article  PubMed  Google Scholar 

  20. Warschkow R, Tarantino I, Ukegjini K, et al. Concomitant cholecystectomy during laparoscopic Roux-en-Y gastric bypass in obese patients is not justified: a meta-analysis. Obes Surg. 2013;23:397–407.

    Article  PubMed  Google Scholar 

  21. Raziel A, Sakran N, Szold A, Goitein D. Concomitant cholecystectomy during laparoscopic sleeve gastrectomy. Surg Endosc. 2015;29:2789–93.

    Article  PubMed  Google Scholar 

  22. Uy MC, Talingdan-Te MC, Espinosa WZ, et al. Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg. 2008;18:1532–8.

    Article  PubMed  Google Scholar 

  23. Adams LB, Chang C, Pope J, et al. Randomized, prospective comparison of ursodeoxycholic acid for the prevention of gallstones after sleeve gastrectomy. Obes Surg. 2015;26(5):990–4.

    Article  Google Scholar 

  24. Miller K, Hell E, Lang B, Lengauer E. Gallstone formation prophylaxis after gastric restrictive procedures for weight loss: a randomized double-blind placebo-controlled trial. Ann Surg. 2003;238:697–702.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Karadeniz M, Gorgun M, Kara C. The evaluation of gallstone formation in patients undergoing Roux-en-Y gastric bypass due to morbid obesity. Ulus Cerrahi Derg. 2014;30:76–9.

    PubMed  PubMed Central  Google Scholar 

  26. Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;21(Suppl 1):S1–27.

    Article  CAS  Google Scholar 

  27. Stokes CS, Gluud LL, Casper M, Lammert F. Ursodeoxycholic acid and diets higher in fat prevent gallbladder stones during weight loss: a meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol. 2014;12:1090–1100 e1092 .quiz e1061

    Article  CAS  PubMed  Google Scholar 

  28. Hempfling W, Dilger K, Beuers U. Systematic review: ursodeoxycholic acid—adverse effects and drug interactions. Aliment Pharmacol Ther. 2003;18:963–72.

    Article  CAS  PubMed  Google Scholar 

  29. Portenier DD, Grant JP, Blackwood HS, et al. Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2007;3:476–9.

    Article  PubMed  Google Scholar 

  30. Lopes TL, Clements RH, Wilcox CM. Laparoscopy-assisted ERCP: experience of a high-volume bariatric surgery center (with video). Gastrointest Endosc. 2009;70:1254–9.

    Article  PubMed  Google Scholar 

  31. Li VK, Pulido N, Fajnwaks P, et al. Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk factors comparing gastric bypass, gastric banding, and sleeve gastrectomy. Surg Endosc. 2009;23:1640–4.

    Article  PubMed  Google Scholar 

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Correspondence to Carlos Zerrweck.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institution and/or national research committee and with 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained for all individual participants included in the study.

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Pineda, O., Maydón, H.G., Amado, M. et al. A Prospective Study of the Conservative Management of Asymptomatic Preoperative and Postoperative Gallbladder Disease in Bariatric Surgery. OBES SURG 27, 148–153 (2017). https://doi.org/10.1007/s11695-016-2264-3

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  • DOI: https://doi.org/10.1007/s11695-016-2264-3

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