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A smartphone-based calibration-free portable urinalysis device

基于智能手机的免校准便携式尿液分析设备

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Abstract

As one of the most common medical diagnosis methods, urinalysis is a highly demanded technique for screening tests or daily monitoring of various diseases. With the rapid development of POC (point-of-care) systems, a convenient house-using urinalysis device is widely needed. However, considering the difference of onboard systems and multiple test indicators in urinalysis, the design of such an intelligent device is still challenging. In this paper, a smartphone-based portable urinalysis system has been developed and applied for the colorimetric analysis of routine urine examination indices using an Android app. By integrating the test paper sensor in the portable device for urinalysis, our system significantly improves the instability of conventional dipstick-based manual colorimetry, and the smartphone application used for color discrimination enhances the accuracy of the visual assessment of sample strips. Using a simple operation approach that takes ∼ 2 min per test, our system can be applied as rapid urinalysis for routine check-ups.

摘要

作为最常见的医学诊断方法, 尿液分析是一种用于筛查测试或日常监测各种疾病的高需求技术。随着POC (point-of-care) 即时医疗系统的快速发展, 人们广泛需要一种方便的家用尿液分析设备。然而, 考虑到机载系统的差异以及尿液分析中的多项测试指标, 这样智能设备的设计仍然具有挑战性。在本文中, 开发了一种基于智能手机的便携式尿液分析系统, 并将其应用于Android 程序进行尿液常规检查中的指标比色分析。通过在便携式尿液分析设备中集成试纸传感器, 我们的系统显着改善了传统基于试纸的手动比色法的不稳定性, 用于颜色辨别的智能手机应用程序提高了样品条视觉评估的准确性。以简单的操作方法和每次约2 min 的测试, 我们的系统可应用于尿液的常规检查和快速分析。

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Funding

Projects(61922093, U1813211) supported by the National Natural Science Foundation of China; Projects (SGDX20201103093003017, JCYJ20200109114827177) supported by Shenzhen Key Basic Research Project, China

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Authors and Affiliations

  1. Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518000, China

    Dong Guo  (郭栋) & Ya-jing Shen  (申亚京)

  2. Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China

    Dong Guo  (郭栋), Gen Li  (李根), Jia-qi Miao  (苗佳麒) & Ya-jing Shen  (申亚京)

Authors
  1. Dong Guo  (郭栋)
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  2. Gen Li  (李根)
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  3. Jia-qi Miao  (苗佳麒)
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  4. Ya-jing Shen  (申亚京)
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Corresponding author

Correspondence to Ya-jing Shen  (申亚京).

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Contributors

GUO Dong and SHEN Ya-jing provided the concept. GUO Dong and LI Gen conducted the literature review and wrote the first draft of the manuscript. GUO Dong and MIAO Jia-qi analyzed the measured data. All authors replied to reviewers’ comments and revised the final version.

Conflict of interest

GUO Dong, LI Gen, MIAO Jia-qi, and SHEN Ya-jing declare that they have no conflict of interest.

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Guo, D., Li, G., Miao, Jq. et al. A smartphone-based calibration-free portable urinalysis device. J. Cent. South Univ. 28, 3829–3837 (2021). https://doi.org/10.1007/s11771-021-4883-7

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  • DOI: https://doi.org/10.1007/s11771-021-4883-7

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