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WNT Signaling and Colorectal Cancer

  • Basic Science Foundations in Colorectal Cancer (J Roper, Section Editor)
  • Published:
Current Colorectal Cancer Reports

Abstract

The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically.

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Acknowledgements

EMS is supported by a Medical Scientist Training Program grant from the National Institute of General Medical Sciences of the National Institutes of Health under award number T32GM07739 to the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program. LED is supported by a K22 Career Development Award from the NCI/NIH (CA 181280-01), with funding from the Starr Cancer Consortium (I8-A8-030) and NIH/NCI (5R01CA195787-02).

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Authors and Affiliations

  1. Sandra and Edward Meyer Cancer Center, New York, NY, USA

    Emma M. Schatoff, Benjamin I. Leach & Lukas E. Dow

  2. Weill Cornell/Rockefeller/Sloan-Kettering Tri-I MD-PhD Program, New York, NY, 10065, USA

    Emma M. Schatoff

  3. New York Presbyterian Hospital, New York, NY, 10021, USA

    Benjamin I. Leach

  4. Department of Medicine, New York, NY, USA

    Lukas E. Dow

  5. Department of Biochemistry, Weill Cornell Medicine, New York, NY, 10021, USA

    Lukas E. Dow

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  1. Emma M. Schatoff
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This article is part of the Topical Collection on Basic Science Foundations in Colorectal Cancer

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Schatoff, E.M., Leach, B.I. & Dow, L.E. WNT Signaling and Colorectal Cancer. Curr Colorectal Cancer Rep 13, 101–110 (2017). https://doi.org/10.1007/s11888-017-0354-9

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